Poor Cosmetic Ingredient NOAEL Data GHS Classified

Barium Chloride

INCI: BARIUM CHLORIDE

CAS Number
10361-37-2
Function
Not a cosmetic ingredient
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not permitted for cosmetic use; barium compounds are toxic

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

9 study endpoints found for Barium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2000 ppm oral mouse oral REACH
NOAEL 2000 ppm oral rat oral REACH
NOAEL 692 ppm oral mouse oral REACH
NOAEL 2500 ppm oral rat oral REACH
LOAEL 2500 ppm oral mouse oral REACH
NOAEL 250 ppm oral rat oral REACH
NOAEL 209 mg/kg bw/day oral rat oral REACH
NOAEL 250 ppm oral rat oral REACH
NOAEL 2000 ppm oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. Exposure could cause hypokalaemia. This may result in cardiac disorders and muscular disorders. Exposure could cause death.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Acute systemic toxicity: cardiotoxic (hypokalemia), neurotoxic, GI toxic; soluble barium salts are among the most hazardous inorganic cosmetic contaminants; LD50 oral (rat) approximately 118 mg/kg

⚠️
Concern Level: High

Regulatory Flags

endocrine_disruptor

Frequently Asked Questions

Is Barium Chloride safe in cosmetics?

Acute systemic toxicity: cardiotoxic (hypokalemia), neurotoxic, GI toxic; soluble barium salts are among the most hazardous inorganic cosmetic contaminants; LD50 oral (rat) approximately 118 mg/kg The EU classifies Barium Chloride as "prohibited". Safety rating: POOR. 9 toxicological study endpoint(s) are available in our database.

Is Barium Chloride allowed in the EU?

Barium Chloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Barium Chloride do in cosmetics?

Barium Chloride functions as: Not a cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 10361-37-2.

What is the Margin of Safety for Barium Chloride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Barium Chloride?

The NOAEL (No Observed Adverse Effect Level) for Barium Chloride is 2000 ppm based on a oral study via oral route in mouse. A total of 9 study endpoints are available. Source: REACH.

Compliance Tools

Check Barium Chloride compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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