NOAEL Studies Cosmetic Ingredient

Ethylhexyl Methacrylate ⚠️ NOAEL Studies

INCI: ETHYLHEXYL METHACRYLATE

CAS: 688-84-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9375; row=5897; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethylhexyl methacrylate; preferred_name=2-Ethylhexyl 2-methyl-2-propenoate; dtxsid=DTXSID3027293; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3027293; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat oral subchronic; 47 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebee4b0a7c65d1cad43; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14761/7/6/2?documentUUID=d7d6f9c2-d48c-427a-8833-0c8b3773d8d3; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847214_15848509:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_563c9f85791dcac6e1d10f8ffc7a4d7e
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1bea6a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14761/7/9/3?documentUUID=d7d6f9c2-d48c-427a-8833-0c8b3773d8d3; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: food consumption and compound intake|maternal: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology; STUDY_GROUP=ECHA IUCLID:15823751:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d2cdf9261dfe7b4bdfff913c4ea004be
ToxValDB_ECHA_IUCLID NOAEL =120 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec8e4b0a7c65d1cae13; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14761/7/6/2?documentUUID=d7d6f9c2-d48c-427a-8833-0c8b3773d8d3; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849749_15849750:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3043d30280585b33e2bee3fc13eecd2d
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1bea6a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14761/7/9/3?documentUUID=d7d6f9c2-d48c-427a-8833-0c8b3773d8d3; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15823444:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5e7aed9d5d6a28c9ff5493b3cf9c67bc
ToxValDB_ECHA_IUCLID NOAEL =360 mg/kg bw/day Rat oral - repeat dose other QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4f24; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14761/7/10/1?documentUUID=d7d6f9c2-d48c-427a-8833-0c8b3773d8d3; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15826074:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c50203cfdd8a1e4436ce76835f996383
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =2.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632036:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f448804c0c7661b838c71b3b5ad4f5ea
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8Q7XLQ325N UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Q7XLQ325N"}
openFDA substances FDA UNII substance identifier 8Q7XLQ325N UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Q7XLQ325N"}
openFDA substances FDA UNII substance identifier 8Q7XLQ325N UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Q7XLQ325N"}
openFDA substances FDA UNII substance identifier 8Q7XLQ325N UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Q7XLQ325N"}