Ethylhexyl Methacrylate ⚠️
INCI: ETHYLHEXYL METHACRYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Ethylhexyl Methacrylate ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 120 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 300 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Known allergen with documented allergic contact dermatitis. Positive mutagenicity in lymphoma cell assay (negative in bacterial Ames). Cross-reactivity with widely used acrylates. Not suitable for leave-on skin products. Risk is mitigated if skin contact is avoided during nail product use.
Regulatory Flags
Frequently Asked Questions
Is Ethylhexyl Methacrylate ⚠️ safe in cosmetics?
Known allergen with documented allergic contact dermatitis. Positive mutagenicity in lymphoma cell assay (negative in bacterial Ames). Cross-reactivity with widely used acrylates. Not suitable for leave-on skin products. Risk is mitigated if skin contact is avoided during nail product use. The EU classifies Ethylhexyl Methacrylate ⚠️ as "permitted". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.
Is Ethylhexyl Methacrylate ⚠️ allowed in the EU?
Ethylhexyl Methacrylate ⚠️ EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexyl Methacrylate ⚠️ do in cosmetics?
Ethylhexyl Methacrylate ⚠️ functions as: Film former (primarily nail enhancement products). It is classified as a cosmetic ingredient in our database. CAS number: 688-84-6.
What is the Margin of Safety for Ethylhexyl Methacrylate ⚠️?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethylhexyl Methacrylate ⚠️?
The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Methacrylate ⚠️ is 120 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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