NOAEL Studies Cosmetic Ingredient

Etidronic Acid NOAEL Studies

INCI: ETIDRONIC ACID

CAS: 2809-21-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 10 mg/kg bw/day dog oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 75 mg/kg bw/day dog oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day rabbit oral 15 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 330.3 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEC =1 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/6/3?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15828519:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f6badd65a33af0c2c345241424b2d73
ToxValDB_ECHA_IUCLID LOAEC =12 mg/m3 Rat inhalation short-term; 14 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/6/3?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15828156:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0cf1d52c571e26138564debbc1bb8252
ToxValDB_ECHA_IUCLID LOAEC =94 mg/m3 Rat inhalation short-term; 14 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/6/3?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15828892:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6897330ebc37c20380f5e280a69f7837
ToxValDB_ECHA_IUCLID LOAEL =169 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/6/2?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15830732:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca60ab8f13caf2e236ead9e1ce1929b7
ToxValDB_ECHA_IUCLID NOAEL >=0.5 mg/m3 Rat inhalation short-term; 14 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/6/3?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827281_15828110:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2d203fcd5acba0ff0294080bd36e26f
ToxValDB_ECHA_IUCLID NOAEL >300 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d23044c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25430/7/9/3?documentUUID=f64258f8-e0fd-4681-957a-3c63eaf94686; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15824751:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a94e5c3ebf45b3077cfbea3eb944d29
ToxValDB_ECHA_IUCLID NOAEL >330 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d23037f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/9/3?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823524_15823562_15823767:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c8b95e0db7537cc9de9ed771b0103b7
ToxValDB_ECHA_IUCLID NOAEL >=384 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8e9e4b0a7c65d21ab57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/9/2?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15855079:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a26c0b9037d5e3a8412e903057195e93
ToxValDB_ECHA_IUCLID NOAEL >=493 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8e9e4b0a7c65d21ab57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/9/2?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15855967:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_32caefcbebd786189001b1dc093b1c01
ToxValDB_ECHA_IUCLID NOAEL >900 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7de6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/9/2?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15861473:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0ff7c94f811b3acfb0f7b7d1e24a2a44
ToxValDB_ECHA_IUCLID NOEL >300 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70f3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16011/7/6/2?documentUUID=1bd1e767-4be3-4528-af30-c0e100609809; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833455_15834764_15850756:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_802a0749bad6bfa74dfee1ae3d866901
ToxValDB_ECHA_IUCLID NOEL >3000 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca90e4b0a7c65d2226f9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25430/7/6/2?documentUUID=f64258f8-e0fd-4681-957a-3c63eaf94686; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833455_15834764_15850756:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e0fd0c03325d5149e4970cade3c14e46
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =12 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632102:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_01b0725e3dba0e53ef31955eb2ae40a4
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOAEL >2880 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de8e4b0a676289de591; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=HESS:15638531:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f0ed24b831433d8f382ee9fe60fa821d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier M2F465ROXU UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H8O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M2F465ROXU"}
openFDA substances FDA UNII substance identifier M2F465ROXU UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H8O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M2F465ROXU"}
openFDA substances FDA UNII substance identifier M2F465ROXU UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H8O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M2F465ROXU"}
openFDA substances FDA UNII substance identifier M2F465ROXU UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H8O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M2F465ROXU"}