NOAEL Studies Cosmetic Ingredient

EUCALYPTUS CITRIODORA OIL NOAEL Studies

CAS: 8000-48-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =100 mg/kg bw/day rat - - NOAEL study 2; 1; 300, p.18
CIR Safety Assessment NOAEL =300 mg/kg rat oral 2 weeks oral toxicity 300; 10; (100, 300, p.18
CIR Safety Assessment NOAEL =1000 mg/kg rat oral 2 weeks oral toxicity 300; 10; (100, 300, p.18
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=12447; Record_ID=skin_sensitization_invivo_2713; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX1031; Formulation_Name=Eucalyptus oil; Concentration=10.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID9034781; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/S0015-6264(75)80165-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034781
NTP ICE skin sensitization Induction dose per skin area 6480 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=12445; Record_ID=skin_sensitization_invivo_2713; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX1031; Formulation_Name=Eucalyptus oil; Concentration=10.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID9034781; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/S0015-6264(75)80165-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034781
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=12451; Record_ID=skin_sensitization_invivo_2713; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX1031; Formulation_Name=Eucalyptus oil; Concentration=10.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID9034781; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/S0015-6264(75)80165-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034781
Regulatory source 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/day rat - - - p.18
Regulatory source oral toxicity 300 mg/kg rat oral 2 weeks oral toxicity p.18
Regulatory source oral toxicity 300 mg/kg/day rat oral - oral toxicity p.18
Regulatory source oral toxicity 1000 mg/kg rat oral 2 weeks oral toxicity p.18
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2R04ONI662 UNII - - - structurallyDiverse -