NOAEL Studies Cosmetic Ingredient

Eugenyl Acetate NOAEL Studies

INCI: EUGENYL ACETATE

CAS: 93-28-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 133 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =300 mg/kg bw/day Rat - 721 days chronic/long term toxicity EFSA FEEDAP - 2011 - OutputID 145 - body weight - systemic - Scientific Opinion on the safety and efficacy of allylhydroxybenzenes (chemical group 18) when used as flavourings for all animal species - doi:10.2903/j.efsa.2011.2440
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1670 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11532; row=9456; data_type=In Vivo; mixture=Chemical; chemical_name=Acetyleugenol; preferred_name=(2-Methoxy-4-prop-2-enylphenyl) acetate; dtxsid=DTXSID5052624; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052624; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11135; Record_ID=skin_sensitization_invivo_2436; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5052624; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90163-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052624
NTP_ICE_skin_sensitization Induction dose per skin area 12960 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11134; Record_ID=skin_sensitization_invivo_2436; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5052624; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12960; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90163-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052624
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11137; Record_ID=skin_sensitization_invivo_2436; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5052624; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90163-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052624
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =300 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=EFSA FEEDAP (2011). Scientific Opinion on the safety and efficacy of allylhydroxybenzenes (chemical group 18) when used as flavourings for all animal species. doi:10.2903/j.efsa.2011.2440.; TITLE=Scientific Opinion on the safety and efficacy of allylhydroxybenzenes (chemical group 18) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2011.2440; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614111:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_690820aca0ae0f74188b54c6bd46c44e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier V9OSB376X8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V9OSB376X8"}
openFDA substances FDA UNII substance identifier V9OSB376X8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V9OSB376X8"}
openFDA substances FDA UNII substance identifier V9OSB376X8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V9OSB376X8"}
openFDA substances FDA UNII substance identifier V9OSB376X8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V9OSB376X8"}