NOAEL Studies
Cosmetic Ingredient
Ferric Chloride NOAEL Studies
INCI: FERRIC CHLORIDE
CAS: 7705-08-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 336 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_skin_irritation 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Breakthrough Time | 14.98 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5021; Record_ID=skin_irritation_invitro_164; Data_Type=In Vitro; Formulation_ID=MIX802; Formulation_Name=Sulfuric acid/ Ferric chloride; Percent_Active_Ingredient=2; Mixture=Mixture; DTXSID=DTXSID8020622; Assay=Corrositex; Endpoint=Breakthrough Time; Response=14.98; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Breakthrough Time | 27.29 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5023; Record_ID=skin_irritation_invitro_89; Data_Type=In Vitro; Concentration=98; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=Corrositex; Endpoint=Breakthrough Time; Response=27.29; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 43.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5018; Record_ID=skin_irritation_invitro_2049; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=43.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 50.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5019; Record_ID=skin_irritation_invitro_2051; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=50.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 28.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5020; Record_ID=skin_irritation_invitro_2053; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=28.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 80.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5014; Record_ID=skin_irritation_invitro_2051; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=80.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 78 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5015; Record_ID=skin_irritation_invitro_2053; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=78; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 77.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5024; Record_ID=skin_irritation_invitro_2049; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=77.60; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 58.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5016; Record_ID=skin_irritation_invitro_2051; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=58.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 89.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5017; Record_ID=skin_irritation_invitro_2053; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020622; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=89.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020622; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020622 |
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =277 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25495/7/6/2?documentUUID=4a101237-b11a-4956-b82a-40df9f6fee29; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840680_15840682:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05a460474293c6e8270ab73ad51fb499 |
| ToxValDB_ECHA_IUCLID | NOAEL | =314 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25495/7/6/2?documentUUID=4a101237-b11a-4956-b82a-40df9f6fee29; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840681_15840683:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b45343cee5e4c006c322e46411eaccf |
| ToxValDB_ECHA_IUCLID | NOAEL | =95 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25495/7/6/2?documentUUID=4a101237-b11a-4956-b82a-40df9f6fee29; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840680_15840682:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2e3a53d9a6ae4e4fe0d3141476c1022c |
| ToxValDB_ECHA_IUCLID | NOAEL | =108 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25495/7/6/2?documentUUID=4a101237-b11a-4956-b82a-40df9f6fee29; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840681_15840683:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_588048552d77f6ee4c094d3c6765e647 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | U38V3ZVV3V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"3Cl.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U38V3ZVV3V"} |
| openFDA substances | FDA UNII substance identifier | U38V3ZVV3V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"3Cl.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U38V3ZVV3V"} |
| openFDA substances | FDA UNII substance identifier | U38V3ZVV3V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"3Cl.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U38V3ZVV3V"} |
| openFDA substances | FDA UNII substance identifier | U38V3ZVV3V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"3Cl.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U38V3ZVV3V"} |