NOAEL Studies Cosmetic Ingredient

Fluorescent Brightener 236 NOAEL Studies

INCI: FLUORESCENT BRIGHTENER 236

CAS: 3426-43-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >15000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_5722; row=16608; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Fluorescent Brightener 213; preferred_name=C.I. Fluorescent Brightener 213; dtxsid=DTXSID90889467; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID90889467; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL ~3300 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20749/7/3/2?documentUUID=9b08d8e7-4e52-4f70-ad6c-ecc70f6a314a; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15809973:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_454f6fd085c1a315f7fc7a87fd9d0650
ToxValDB_ECHA_IUCLID NOAEL =750 mg/kg bw/day Dog oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c7a29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20749/7/6/2?documentUUID=9b08d8e7-4e52-4f70-ad6c-ecc70f6a314a; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15848186:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6738ae1a0a1b25fb1f60445e9c6763c1
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b817d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20749/7/9/2?documentUUID=9b08d8e7-4e52-4f70-ad6c-ecc70f6a314a; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=F1: viability|F1: sexual maturation|F1: clinical signs|F1: body weight and weight gain|F1: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|development|food and/or water consumption|reproduction; STUDY_GROUP=ECHA IUCLID:15863118:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_223647f474ede6be878c1188ff414a57
ToxValDB_ECHA_IUCLID NOAEL =937.5 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8173; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20749/7/9/2?documentUUID=9b08d8e7-4e52-4f70-ad6c-ecc70f6a314a; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15863148:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_679e55c31346b1e4efa211e46b525dff