Regulatory Status
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Safety Data
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Expert Verdict
Permitted in EU under general safety provisions with no Annex restrictions; however, EFSA FEEDAP Panel (2021, 2023) identified unresolved genotoxicity concerns for constituent gentiopicroside and xanthones (gentisin, isogentisin) due to potential DNA adduct formation, with no dermal absorption or sensitization data available to establish adequate margin of safety for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Gentiana Lutea Root Extract safe in cosmetics?
Permitted in EU under general safety provisions with no Annex restrictions; however, EFSA FEEDAP Panel (2021, 2023) identified unresolved genotoxicity concerns for constituent gentiopicroside and xanthones (gentisin, isogentisin) due to potential DNA adduct formation, with no dermal absorption or sensitization data available to establish adequate margin of safety for cosmetic use. The EU classifies Gentiana Lutea Root Extract as "permitted". Safety rating: MODERATE.
Is Gentiana Lutea Root Extract allowed in the EU?
Gentiana Lutea Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gentiana Lutea Root Extract do in cosmetics?
Gentiana Lutea Root Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 72968-42-4.
What is the Margin of Safety for Gentiana Lutea Root Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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