NOAEL Studies Cosmetic Ingredient

Geranyl Acetate NOAEL Studies

INCI: GERANYL ACETATE

CAS: 105-87-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 84 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4000 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =6330 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_498; row=430; data_type=In Vivo; mixture=Chemical; chemical_name=Geranyl acetate; preferred_name=Geranyl acetate; dtxsid=DTXSID0020654; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020654; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 823 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=73; Record_ID=adme_parameters_974; Data_Type=Measured; DTXSID=DTXSID0020654; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=823.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_adme_parameters Fu 0.192 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=72; Record_ID=adme_parameters_974; Data_Type=Measured; DTXSID=DTXSID0020654; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.192; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer Top dose 1000 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=255; Record_ID=cancer_2241; Data_Type=In Vivo; Formulation_Name=Geranyl acetate; Mixture=Chemical; DTXSID=DTXSID0020654; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1000; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-252; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr252/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_cancer Top dose 2000 mg/kg bw/day Rat Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=252; Record_ID=cancer_2242; Data_Type=In Vivo; Formulation_Name=Geranyl acetate; Mixture=Chemical; DTXSID=DTXSID0020654; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-252; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr252/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9982; RecordID=ARPathway2016_462; DatasetName=ARPathway2016; DTXSID=DTXSID0020654; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2787; Record_ID=skin_sensitization_invivo_741; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020654; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90167-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_skin_sensitization Induction dose per skin area 2483 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2786; Record_ID=skin_sensitization_invivo_741; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020654; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2483; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90167-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
NTP_ICE_skin_sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2789; Record_ID=skin_sensitization_invivo_741; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020654; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90167-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020654; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020654
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c4732; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5472/7/6/2?documentUUID=8f65a091-635f-437d-be7d-c98b1a9c06f5; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15847337:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9382c48324c41333de8f400de50443a7
ToxValDB_ECHA_IUCLID NOAEL =2000 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c472e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5472/7/6/2?documentUUID=8f65a091-635f-437d-be7d-c98b1a9c06f5; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15847984:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a30b69c9ee8c5e3b0155a8467925cf56
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =2000 mg/kg bw/day Mouse oral short-term; 2 days short-term LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607528_15607529:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=da4594dd1bab6c78df43dd7e431a5740
ToxValDB_ECOTOX NOEL =2000 mg/kg bw/day Rat oral short-term; 2 days short-term LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15602853:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=18635b91d729c06512b6e80d388ffdd5
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =345 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4512.; TITLE=Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4512; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15622559:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f8837f29f5592b9fbdd0641d87652e84
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =62.59 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632381:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad97a539f2bc0794477972483a40a9b6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3W81YG7P9R UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3W81YG7P9R"}
openFDA substances FDA UNII substance identifier 3W81YG7P9R UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3W81YG7P9R"}
openFDA substances FDA UNII substance identifier 3W81YG7P9R UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3W81YG7P9R"}
openFDA substances FDA UNII substance identifier 3W81YG7P9R UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3W81YG7P9R"}