Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Glucose. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 68000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 16000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 40000 mg/kg bw/day | oral | monkey | Short Term Toxicity | COSMOS_DB |
| NOAEL | 24000 mg/kg bw/day | oral | swine | Short Term Toxicity | COSMOS_DB |
| NOAEL | 68000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 105000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 77000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 65000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 56000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 68000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Glucose is an endogenous metabolite and GRAS substance with unrestricted cosmetic use globally, with CIR Panel concluding all monosaccharides and disaccharides safe as used.
Regulatory Flags
Frequently Asked Questions
Is Glucose safe in cosmetics?
Glucose is an endogenous metabolite and GRAS substance with unrestricted cosmetic use globally, with CIR Panel concluding all monosaccharides and disaccharides safe as used. The EU classifies Glucose as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Glucose allowed in the EU?
Glucose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucose do in cosmetics?
Glucose functions as: Humectant, Skin Conditioning, Flavoring Agent. It is classified as a Cosmetic Ingredient in our database. CAS number: 50-99-7.
What is the Margin of Safety for Glucose?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Glucose?
The NOAEL (No Observed Adverse Effect Level) for Glucose is 68000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Glucose compliance across multiple jurisdictions:
Related Ingredients
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