What is the NOAEL for D-Glucose?
D-Glucose has 24 NOAEL studies in the database. The lowest reported value is 0.1 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
D-Glucose
Also known as: Dextrose, Glucose – C6H12O6, glucosa, Glucose, 4-01-00-04302 (+14 more)
CAS 50-99-7
D-Glucose (CAS 50-99-7) is a chemical substance. Key regulatory status: 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
24
SOURCE
Chemical inventory jurisdictions
Regulatory lists
10
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
D-Glucose
CAS Number
50-99-7
Molecular Formula
C6H12O6
InChI Key
GZCGUPFRVQAUEE-SLPGGIOYSA-N
Monoisotopic Mass
180.063388
Synonyms
DextroseGlucose – C6H12O6glucosaGlucose4-01-00-04302Blood sugarBRN 1724615Dextrose, anhydrousEINECS 200-075-1Glucose, anhydrousGlucose liquidNSC 406891
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
54 records
HumectantFlavouring and nutrientPharmaceuticalBinderFragranceProcessing aids not otherwise specifiedDrierSolventThickening agentDyeAnti-caking agentLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.1 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 15.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 5SL0G7R0OK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >3000 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 1.074 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1.17 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 2500 | mg/kg bw/day | NOAEL | oral | swine | COSMOS DB |
| 1.000e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 1.500e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1.600e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 2.000e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 2.400e+4 | mg/kg bw/day | NOAEL | oral | swine | COSMOS DB |
| 4.000e+4 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS DB |
| 4.700e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 5.000e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 5.600e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 6.000e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 6.500e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 6.800e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 6.900e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 7.300e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 7.700e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1.050e+5 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
Showing 24 of 24 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL448805
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include D-Glucose?
D-Glucose appears on 9 regulatory/inventory lists including IFRA Transparency, SCIL (9/2019), Canada; pharmaceutical, and 6 more. Source: EPA CPDat.
Is D-Glucose used in cosmetics?
Yes, D-Glucose is also indexed as a cosmetic ingredient under the name Glucose. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D-Glucose come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is D-Glucose used outside industrial chemicals?
D-Glucose also appears in cosmetics, pharmaceutical, food safety, cannabis databases.