NOAEL Studies
Cosmetic Ingredient
Glutaric Acid NOAEL Studies
INCI: GLUTARIC ACID
CAS: 110-94-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =6000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1449; row=3964; data_type=In Vivo; mixture=Chemical; chemical_name=Pentanedioic acid; preferred_name=Glutaric acid; dtxsid=DTXSID2021654; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021654; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021654; source_file=acute_oral.xlsx |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =11.52 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632399:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a32ed1a28240d82257fee9f141b79c43 |
ToxValDB HPVIS 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =2 | % diet | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Solutia Inc. (1968). Unpublished Data, BT-68-26A, "Ninety-Day Subacute Oral Toxicity of Glutaric Acid, Albino Rats" (April).; TITLE=Unpublished Data, BT-68-26A, "Ninety-Day Subacute Oral Toxicity of Glutaric Acid, Albino Rats" (April); AUTHOR=Solutia Inc; EXTERNAL_SOURCE_ID=61061; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639660_15639696:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b176f9a85fdf3428b79eae5b12b048ef |
| ToxValDB HPVIS | LOAEL | =400 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=Sterling-Winthrop Research Institute (1984). Unpublished Data, "A Teratology Study in Albino Rats Medicated Orally" (January 5).Bradford, J.C. et al. (1984). Teratology, 29(2):19A.; EXTERNAL_SOURCE_ID=58623; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642385_15642514:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3dd98f3cb3c83e91baf2baddc0444220 |
| ToxValDB HPVIS | NOAEL | >=1 | % diet | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Solutia Inc. (1968). Unpublished Data, BT-68-26A, "Ninety-Day Subacute Oral Toxicity of Glutaric Acid, Albino Rats" (April).; TITLE=Unpublished Data, BT-68-26A, "Ninety-Day Subacute Oral Toxicity of Glutaric Acid, Albino Rats" (April); AUTHOR=Solutia Inc; EXTERNAL_SOURCE_ID=60811; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639660_15639696:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c70d4c36fc1118a5ec1c817a6f8c258 |
| ToxValDB HPVIS | NOAEL | >=2 | % diet | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Solutia Inc. (1968). Unpublished Data, BT-68-26B, "Ninety-Day Subacute Oral Toxicity of Glutaric Acid in Beagle Dogs" (April).Additional References for Repeat Dose Toxicity: Data from these additional sources support the study results summarized above. These studies were not chosen for detailed summarization because the data were not substantially additive to the database.)Solutia Inc. (1977). Unpublished Data, BD-77-16A, "A Four Week Dose-RangeFinding Study of Glutaric Acid in Rats" (July).Solutia Inc. (1977). Unpublished Data, BD-77-17A, "A Four Week Dose-RangeFinding Study of Glutaric Acid in Dogs" (February).DuPont Co. (1944). Unpublished Data, Haskell Laboratory Report No. 14-44, "Preliminary Tests on New Materials" (June 14).; EXTERNAL_SOURCE_ID=62644; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639919:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a899be516ad47c3797e9444d8c3d41f3 |
| ToxValDB HPVIS | NOAEL | =125 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=Sterling-Winthrop Research Institute (1984). Unpublished Data, "A Teratology Study in Albino Rats Medicated Orally" (January 5).Bradford, J.C. et al. (1984). Teratology, 29(2):19A.; EXTERNAL_SOURCE_ID=58224; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642385_15642514:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_021fc600049af15d8a21a6328906f22d |
| ToxValDB HPVIS | NOAEL | >500 | mg/kg bw/day | Rabbit | oral | short-term; 13 days | reproduction developmental | LONG_REF=Sterling-Winthrop Research Institute (1984). Unpublished Data, "A Teratology Study in New Zealand White Rabbits Medicated Orally" (March 22).Bradford, J. C. et al. (1984). Teratology, 29(2):19A; EXTERNAL_SOURCE_ID=58624; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642515:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_97a27cc9c47a1cd90292b002ef0f4135 |
| ToxValDB HPVIS | NOAEL | >=1000 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=Solutia Inc. (1977). Unpublished Data, BD-77-20A, "Pilot Study to Evaluate the Toxicity of Glutaric Acid in Pregnant Rats" (June).; TITLE=Unpublished Data, BD-77-20A, "Pilot Study to Evaluate the Toxicity of Glutaric Acid in Pregnant Rats" (June); AUTHOR=Solutia Inc; EXTERNAL_SOURCE_ID=57869; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642277:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bc0d089969b5737e346e505669428e48 |
| ToxValDB HPVIS | NOAEL | =1300 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=Sterling-Winthrop Research Institute (1984). Unpublished Data, "A Teratology Study in Albino Rats Medicated Orally" (January 5).Bradford, J.C. et al. (1984). Teratology, 29(2):19A.; EXTERNAL_SOURCE_ID=57868; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642276:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ed155a27ed514a8e84c15976931aef12 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | H849F7N00B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H849F7N00B"} |
| openFDA substances | FDA UNII substance identifier | H849F7N00B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H849F7N00B"} |
| openFDA substances | FDA UNII substance identifier | H849F7N00B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H849F7N00B"} |
| openFDA substances | FDA UNII substance identifier | H849F7N00B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H849F7N00B"} |