Is Glutaric Acid safe in cosmetics?
Glutaric Acid has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Glutaric Acid
Also known as: Pentanedioic acid, 4-02-00-01934, BRN 1209725, EINECS 203-817-2, n-Pyrotartaric acid (+8 more)
INCI: GLUTARIC ACID
Glutaric Acid (CAS 110-94-1) is a cosmetic cosmetic ingredient functioning as Buffering. NOAEL 1720 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-94-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Glutaric Acid is classified GHS Danger (H314, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Buffering
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
pentanedioic acid
InChIKey
JFCQEDHGNNZCLN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR reviewed; not restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glutaric Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Glutaric Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
1367
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Processing aids not otherwise specified
pH regulating agent
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Glutaric Acid.
Regulatory Flags
epa_safer_alternative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Glutaric Acid by CAS number or substance name.
Studies
9
Lowest NOAEL
980 mg/kg bw/day
Highest NOAEL
1960 mg/kg bw/day
ECHA
Known Synonyms
Pentanedioic acid
4-02-00-01934
BRN 1209725
EINECS 203-817-2
n-Pyrotartaric acid
UNII-H849F7N00B
1,3-Propanedicarboxylate
1,5-Pentanedioate
Glutarate
Glutarsaeure
Pentandioate
Pentandioic acid
Pentanedioate
Chemical Function
pH regulating agent
Flavouring and nutrient
Processing aids not otherwise specified
Regulatory Lists
Europe
SCIL (9/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GLUTARATE
ChEMBL ID
CHEMBL1162495
Frequently Asked Questions
Is Glutaric Acid allowed in the EU?
Glutaric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glutaric Acid do in cosmetics?
Glutaric Acid functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 110-94-1.
Is Glutaric Acid used outside cosmetics?
Glutaric Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Glutaric Acid have different safety status in cosmetics vs industrial chemicals?
Glutaric Acid is classified GHS Danger (H314, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Glutaric Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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