Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Glutaric Acid

INCI: GLUTARIC ACID

CAS Number
110-94-1
Function
Buffering
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR reviewed; not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Glutaric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1720 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.

Expert Verdict

Classified as irritant/corrosive with pH-dependent irritation risk. Must be formulated at controlled pH (4.5โ€“6.5 for skin compatibility). Appropriate for buffering systems at low concentrations only. Incompatible with bases and oxidizing agents.

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Concern Level: Moderate

Regulatory Flags

epa_safer_alternative

Frequently Asked Questions

Is Glutaric Acid safe in cosmetics?

Classified as irritant/corrosive with pH-dependent irritation risk. Must be formulated at controlled pH (4.5โ€“6.5 for skin compatibility). Appropriate for buffering systems at low concentrations only. Incompatible with bases and oxidizing agents. The EU classifies Glutaric Acid as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Glutaric Acid allowed in the EU?

Glutaric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glutaric Acid do in cosmetics?

Glutaric Acid functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 110-94-1.

What is the Margin of Safety for Glutaric Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Glutaric Acid?

The NOAEL (No Observed Adverse Effect Level) for Glutaric Acid is 1720 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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