NOAEL Studies Cosmetic Ingredient

Glycidoxypropyl Trimethoxysilane NOAEL Studies

INCI: GLYCIDOXYPROPYL TRIMETHOXYSILANE

CAS: 2530-83-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE eye irritation 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1577; Record_ID=eye_irritation_163; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5027489; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=2; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027489
NTP ICE eye irritation Intensity 0.11 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1579; Record_ID=eye_irritation_1226; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5027489; Assay=Vitrigel; Endpoint=Intensity; Response=0.11; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027489
NTP ICE eye irritation Lag time 0 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1578; Record_ID=eye_irritation_1226; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5027489; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027489
NTP ICE eye irritation Plateau level 20.2 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1580; Record_ID=eye_irritation_1226; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5027489; Assay=Vitrigel; Endpoint=Plateau level; Response=20.2; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027489
ECHA 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =2000 mg/kg bw/day Rat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/3/2?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15811239:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dee56ed98609520c691b39ef594db963
ECHA NOAEC =225 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/6/3?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15827855:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79ac3fbe6c45626049300eb318c946f0
ECHA NOAEL >11.1 mg/kg bw/day Mouse dermal - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216d64; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/8?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15817278:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_269bd8e19bd423b5d0854b73dcdb76f8
ECHA NOAEL >=400 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/9/3?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15823775:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d3b8939ea9b920fd6728bd842a47116
ECHA NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/9/2?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855008_15862750:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ebf2437e736276d55fddfac14aeec62
ECHA NOAEL >=1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/9/3?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15824635:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82e7b0c496d03fdc025df52cfb79ef17
ECHA NOAEL =1500 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14972/7/9/3?documentUUID=cff1e170-a54c-4e7e-b4ab-946c40248855; YEAR=1973; ORIGINAL_YEAR=1973; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824636:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_00f9b1f7cec472da6c4a837bb3df0765
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =70.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631843_15631844:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d1bff0cb588ac346ae646932a6a119b
ToxValDB GESTIS DNEL DNEL systemic =260 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631843_15631844:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cec5c1cf7ddae0262ce39b03284dc504
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOAEL >1000 mg/kg bw/day Rat oral short-term; 28 days short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd9e4b0a676289dde41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Deaths: None (there were dead animals due to intubation error); STUDY_GROUP=HESS:15638744:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5581e602f52fec4284146283ec93e1e6
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5K9X9X899R UNII - - - chemical -