Is Glycidoxypropyl Trimethoxysilane safe in cosmetics?
Glycidoxypropyl Trimethoxysilane has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Glycidoxypropyl Trimethoxysilane
Also known as: BRN 4308125, EINECS 219-784-2, 3-(2,3-Epoxypropoxy)propyltrimethoxysilane, (3-(Glycidyloxy)propyl)trimethoxysilane, Silan A 187 (+6 more)
INCI: GLYCIDOXYPROPYL TRIMETHOXYSILANE
Glycidoxypropyl Trimethoxysilane (CAS 2530-83-8) is a cosmetic cosmetic ingredient functioning as Coupling agent / adhesion promoter (primarily industrial; occasional cosmetic. Reported NOAEL =500 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2530-83-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Glycidoxypropyl Trimethoxysilane is prohibited in EU cosmetics but has active industrial GHS classifications (H318, H341, H412, H315, H319, H335, H402).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Coupling agent / adhesion promoter (primarily industrial; occasional cosmetic crosslinker use)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane
InChIKey
BPSIOYPQMFLKFR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No specific CFR cosmetic prohibition; however, not a typical cosmetic ingredient; OSHA workplace exposure limits apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycidoxypropyl Trimethoxysilane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Glycidoxypropyl Trimethoxysilane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1500 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Chemical reaction regulator
Hardener
Softener and conditioner
Thickening agent
Viscosity modifier
Wetting agent (non-aqueous)
Expert Verdict
Expert safety assessment and concern-level summary for Glycidoxypropyl Trimethoxysilane.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Glycidoxypropyl Trimethoxysilane by CAS number or substance name.
Studies
2
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
BRN 4308125
EINECS 219-784-2
3-(2,3-Epoxypropoxy)propyltrimethoxysilane
(3-(Glycidyloxy)propyl)trimethoxysilane
Silan A 187
Silane-y-4087
Silicone A-187
Silicone KBM 403
((3-(Trimethoxysilyl)propoxy)methyl)oxirane
Union carbide a-187
UNII-5K9X9X899R
Chemical Function
Softener and conditioner
Adhesion/cohesion promoter
Viscosity modifier
Chemical reaction regulator
Regulatory Lists
CEDI
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2140162
Frequently Asked Questions
Is Glycidoxypropyl Trimethoxysilane allowed in the EU?
Glycidoxypropyl Trimethoxysilane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycidoxypropyl Trimethoxysilane do in cosmetics?
Glycidoxypropyl Trimethoxysilane functions as: Coupling agent / adhesion promoter (primarily industrial; occasional cosmetic crosslinker use). It is classified as a cosmetic ingredient in our database. CAS number: 2530-83-8.
What is the NOAEL for Glycidoxypropyl Trimethoxysilane?
The NOAEL (No Observed Adverse Effect Level) for Glycidoxypropyl Trimethoxysilane is =500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Glycidoxypropyl Trimethoxysilane used outside cosmetics?
Glycidoxypropyl Trimethoxysilane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Glycidoxypropyl Trimethoxysilane have different safety status in cosmetics vs industrial chemicals?
Glycidoxypropyl Trimethoxysilane is prohibited in EU cosmetics but has active industrial GHS classifications (H318, H341, H412, H315, H319, H335, H402).
Compliance Tools
Check Glycidoxypropyl Trimethoxysilane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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