NOAEL Studies Cosmetic Ingredient

GLYCOL NOAEL Studies

CAS: 107-21-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source NOAEL =23 mg/m3 Human (M) inhalation short-term; 30 days clinical ATSDR MRLs; row_hash=5f12f5bc8b36fc5d; source_hash=ToxValhc_f0e7d413b26f7be301a9f1b4f7f8ced5; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=23; raw_unit=mg/m3; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Wills JH, Coulston F, Harris ES, et al. 1974. Inhalation of aerosolized ethylene glycol by man. Clin Toxicol 7(5):463-476.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575e
Regulatory source NOAEL =200 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=462de0a405ba5861; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 2.00e2 mg/kg-day; system=Urinary; basis=Kidney toxicity; point_of_departure=NOAEL : 2.00e2 mg/kg-day; composite_uf=100; confidence=High; dtxsid=DTXSID8020597; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=238; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0238_summary.pdf
Regulatory source RfD =2 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=8ca482717387990f; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2; system=Urinary; basis=Kidney toxicity; point_of_departure=NOAEL : 2.00e2 mg/kg-day; composite_uf=100; confidence=High; dtxsid=DTXSID8020597; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=238; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0238_summary.pdf
COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 300 mg/kg bw/day rat oral 1 year Chronic REACH; Dow K-002558-022 / Corley et al.
COSMOS DB NOAEL 150 mg/kg bw/day rat oral 1 year Chronic REACH; Dow K-002558-022 / Corley et al.
California Proposition 65 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 MADL ABoral=8700 ug/day - - 2015-06-19 Maximum allowable dose level {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL ABoral=8700 ug/day - - 2015-06-19 Maximum allowable dose level {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL ABoral=8700 ug/day - - 2015-06-19 Maximum allowable dose level {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL ABoral=8700 ug/day - - 2015-06-19 Maximum allowable dose level {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2015-06-19 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2015-06-19 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2015-06-19 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2015-06-19 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2015-06-19","listing_mechanism":"AB","madl":"oral=8700","nsrl":null,"source_table":"prop65_listings"}
FDA 36 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
FDA NOEL <=6000 mg/kg bw/day rabbit (Himalayan; male/female) oral: gavage GD 6-20 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Study of embryo fetal development in rabbits by oral administration_17524/03 - c8be8eb2-3f55-4ca2-a5ff-a13484301770/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: visceral malformations: no abnormal phenotype detected
FDA NOEL <=6000 mg/kg bw/day rabbit (Himalayan; male/female) oral: gavage GD 6-20 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Study of embryo fetal development in rabbits by oral administration_17524/03 - c8be8eb2-3f55-4ca2-a5ff-a13484301770/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: visceral malformations: no abnormal phenotype detected
FDA NOEL <=6000 mg/kg bw/day rabbit (Himalayan; male/female) oral: gavage GD 6-20 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Study of embryo fetal development in rabbits by oral administration_17524/03 - c8be8eb2-3f55-4ca2-a5ff-a13484301770/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: visceral malformations: no abnormal phenotype detected
FDA NOEL <=6000 mg/kg bw/day rabbit (Himalayan; male/female) oral: gavage GD 6-20 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Study of embryo fetal development in rabbits by oral administration_17524/03 - c8be8eb2-3f55-4ca2-a5ff-a13484301770/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: visceral malformations: no abnormal phenotype detected
FDA NOEL <=8000 mg/kg bw/day rat (Wistar; male/female) oral: feed 2 years carcinogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - Carcinogenicity - 2-years repeated dose oral feeding to rats_1 - f74c9a34-9d6d-4a93-b662-6caf28f2e406/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: mortality
FDA NOEL <=8000 mg/kg bw/day rat (Wistar; male/female) oral: feed 2 years carcinogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - Carcinogenicity - 2-years repeated dose oral feeding to rats_1 - f74c9a34-9d6d-4a93-b662-6caf28f2e406/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: mortality
FDA NOEL <=8000 mg/kg bw/day rat (Wistar; male/female) oral: feed 2 years carcinogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - Carcinogenicity - 2-years repeated dose oral feeding to rats_1 - f74c9a34-9d6d-4a93-b662-6caf28f2e406/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: mortality
FDA NOEL <=8000 mg/kg bw/day rat (Wistar; male/female) oral: feed 2 years carcinogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - Carcinogenicity - 2-years repeated dose oral feeding to rats_1 - f74c9a34-9d6d-4a93-b662-6caf28f2e406/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: mortality
FDA NOEL <=20000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 2 weeks repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 2-week oral toxicity study in rats_18290/04 - 185a4440-a849-4649-a725-9c31380aff76/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: histopathology: non-neoplastic: no abnormal phenotype detected
FDA NOEL <=20000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 2 weeks repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 2-week oral toxicity study in rats_18290/04 - 185a4440-a849-4649-a725-9c31380aff76/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: histopathology: non-neoplastic: no abnormal phenotype detected
FDA NOEL <=20000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 2 weeks repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 2-week oral toxicity study in rats_18290/04 - 185a4440-a849-4649-a725-9c31380aff76/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: histopathology: non-neoplastic: no abnormal phenotype detected
FDA NOEL <=20000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 2 weeks repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 2-week oral toxicity study in rats_18290/04 - 185a4440-a849-4649-a725-9c31380aff76/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: histopathology: non-neoplastic: no abnormal phenotype detected
FDA NOEL <=40000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral segment II embryo fetal development study in rats_17522/03 - 73b39fca-360b-41d5-a05f-4261e9d1c8a4/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: external malformations: no abnormal phenotype detected
FDA NOEL <=40000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral segment II embryo fetal development study in rats_17522/03 - 73b39fca-360b-41d5-a05f-4261e9d1c8a4/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: external malformations: no abnormal phenotype detected
FDA NOEL <=40000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral segment II embryo fetal development study in rats_17522/03 - 73b39fca-360b-41d5-a05f-4261e9d1c8a4/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: external malformations: no abnormal phenotype detected
FDA NOEL <=40000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral segment II embryo fetal development study in rats_17522/03 - 73b39fca-360b-41d5-a05f-4261e9d1c8a4/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: external malformations: no abnormal phenotype detected
FDA NOEL <=60000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 90 days repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 90-day oral toxicity study in rats_17519/03 - e6acc222-a986-4a07-ae91-814da543f960/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: ophthalmological examination: no abnormal phenotype detected
FDA NOEL <=60000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 90 days repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 90-day oral toxicity study in rats_17519/03 - e6acc222-a986-4a07-ae91-814da543f960/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: ophthalmological examination: no abnormal phenotype detected
FDA NOEL <=60000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 90 days repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 90-day oral toxicity study in rats_17519/03 - e6acc222-a986-4a07-ae91-814da543f960/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: ophthalmological examination: no abnormal phenotype detected
FDA NOEL <=60000 mg/kg bw/day rat (Crj: CD(SD); male/female) oral: gavage 90 days repeated dose toxicity oral 5c920908-d1ec-4fa1-ae9b-6870804637fb_dossier.i6z - RepeatedDoseToxicityOral - 90-day oral toxicity study in rats_17519/03 - e6acc222-a986-4a07-ae91-814da543f960/b47a82f7-ace5-4769-9e42-03270764a1bb - basis: ophthalmological examination: no abnormal phenotype detected
FDA NOEL <=2000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - DevelopmentalToxicityTeratogenicity - Embryofetal development (segment II) in rats_382013 - 188e0ad7-c929-4c8f-9bec-0e09b65feab9/1d2c2797-92ef-4900-9da2-53902f562599 - basis: food consumption and compound intake: no abnormal phenotype detected
FDA NOEL <=2000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - DevelopmentalToxicityTeratogenicity - Embryofetal development (segment II) in rats_382013 - 188e0ad7-c929-4c8f-9bec-0e09b65feab9/1d2c2797-92ef-4900-9da2-53902f562599 - basis: food consumption and compound intake: no abnormal phenotype detected
FDA NOEL <=2000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - DevelopmentalToxicityTeratogenicity - Embryofetal development (segment II) in rats_382013 - 188e0ad7-c929-4c8f-9bec-0e09b65feab9/1d2c2797-92ef-4900-9da2-53902f562599 - basis: food consumption and compound intake: no abnormal phenotype detected
FDA NOEL <=2000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage GD 6-17 developmental toxicity teratogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - DevelopmentalToxicityTeratogenicity - Embryofetal development (segment II) in rats_382013 - 188e0ad7-c929-4c8f-9bec-0e09b65feab9/1d2c2797-92ef-4900-9da2-53902f562599 - basis: food consumption and compound intake: no abnormal phenotype detected
FDA NOEL <=3000 mg/kg bw/day dog (Beagle; male/female) oral: gavage 9 months repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 9-month oral gavage toxicity study in dogs_ - 3c2d53ce-d597-4440-b59b-49568bd76e7f/1d2c2797-92ef-4900-9da2-53902f562599 - basis: haematology: no abnormal phenotype detected
FDA NOEL <=3000 mg/kg bw/day dog (Beagle; male/female) oral: gavage 9 months repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 9-month oral gavage toxicity study in dogs_ - 3c2d53ce-d597-4440-b59b-49568bd76e7f/1d2c2797-92ef-4900-9da2-53902f562599 - basis: haematology: no abnormal phenotype detected
FDA NOEL <=3000 mg/kg bw/day dog (Beagle; male/female) oral: gavage 9 months repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 9-month oral gavage toxicity study in dogs_ - 3c2d53ce-d597-4440-b59b-49568bd76e7f/1d2c2797-92ef-4900-9da2-53902f562599 - basis: haematology: no abnormal phenotype detected
FDA NOEL <=3000 mg/kg bw/day dog (Beagle; male/female) oral: gavage 9 months repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 9-month oral gavage toxicity study in dogs_ - 3c2d53ce-d597-4440-b59b-49568bd76e7f/1d2c2797-92ef-4900-9da2-53902f562599 - basis: haematology: no abnormal phenotype detected
FDA NOEL <=6000 mg/kg bw/day mouse (CD-1; male/female) oral: gavage 104 weeks carcinogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - Carcinogenicity - 104-week oral gavage carcinogenicity srudy in CD-1 mice_382018 - 1aea4566-f6bc-4e16-9905-afd36a1eae11/1d2c2797-92ef-4900-9da2-53902f562599 - basis: body weight and weight gain
FDA NOEL <=6000 mg/kg bw/day mouse (CD-1; male/female) oral: gavage 104 weeks carcinogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - Carcinogenicity - 104-week oral gavage carcinogenicity srudy in CD-1 mice_382018 - 1aea4566-f6bc-4e16-9905-afd36a1eae11/1d2c2797-92ef-4900-9da2-53902f562599 - basis: body weight and weight gain
FDA NOEL <=6000 mg/kg bw/day mouse (CD-1; male/female) oral: gavage 104 weeks carcinogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - Carcinogenicity - 104-week oral gavage carcinogenicity srudy in CD-1 mice_382018 - 1aea4566-f6bc-4e16-9905-afd36a1eae11/1d2c2797-92ef-4900-9da2-53902f562599 - basis: body weight and weight gain
FDA NOEL <=6000 mg/kg bw/day mouse (CD-1; male/female) oral: gavage 104 weeks carcinogenicity a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - Carcinogenicity - 104-week oral gavage carcinogenicity srudy in CD-1 mice_382018 - 1aea4566-f6bc-4e16-9905-afd36a1eae11/1d2c2797-92ef-4900-9da2-53902f562599 - basis: body weight and weight gain
FDA NOEL <=9300 mg/kg bw/day dog (Beagle; male/female) oral: gavage 28 days repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 28-day oral gavage toxicity study in dogs_382005 - e6a17061-119d-42bf-8762-8dcbc9cb54aa/1d2c2797-92ef-4900-9da2-53902f562599 - basis: organ weights and organ / body weight ratios: no abnormal phenotype detected
FDA NOEL <=9300 mg/kg bw/day dog (Beagle; male/female) oral: gavage 28 days repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 28-day oral gavage toxicity study in dogs_382005 - e6a17061-119d-42bf-8762-8dcbc9cb54aa/1d2c2797-92ef-4900-9da2-53902f562599 - basis: organ weights and organ / body weight ratios: no abnormal phenotype detected
FDA NOEL <=9300 mg/kg bw/day dog (Beagle; male/female) oral: gavage 28 days repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 28-day oral gavage toxicity study in dogs_382005 - e6a17061-119d-42bf-8762-8dcbc9cb54aa/1d2c2797-92ef-4900-9da2-53902f562599 - basis: organ weights and organ / body weight ratios: no abnormal phenotype detected
FDA NOEL <=9300 mg/kg bw/day dog (Beagle; male/female) oral: gavage 28 days repeated dose toxicity oral a97ec50a-b512-4764-9479-28cdb62996f6_dossier.i6z - RepeatedDoseToxicityOral - 28-day oral gavage toxicity study in dogs_382005 - e6a17061-119d-42bf-8762-8dcbc9cb54aa/1d2c2797-92ef-4900-9da2-53902f562599 - basis: organ weights and organ / body weight ratios: no abnormal phenotype detected
WHO/JECFA 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA LOAEL =180 mg/kg bw/day - - - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=70822253f9b42fdd; raw_unit=mg/kg body weight per day; context=LOAEL = 180 mg/kg body weight per day [males]).
WHO/JECFA LOAEL =1000 mg/kg bw/day - - - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=3689f6923dcdb1ad; raw_unit=mg/kg body weight per day; context=LOAEL (offspring) = 1000 mg/kg body weight per day;
WHO/JECFA LOAEL =1500 mg/kg bw/day - - - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=03b753ef3b2914b1; raw_unit=mg/kg body weight per day; context=LOAEL (offspring) = 1500 mg/kg body weight per day;
WHO/JECFA NOAEL =71 mg/kg bw/day - - - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=552f6faec0d4bad8; raw_unit=mg/kg body weight per day; context=, there were four dose levels of 35, 71, 180, and 715 mg/kg body weight per day, including two at which there was a significant increase of ethylene glycol-related tubular damage (NOAEL = 71 mg/kg body weight per day [males];
WHO/JECFA NOAEL =500 mg/kg bw/day - - - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=7b4c9e9951c9bef9; raw_unit=mg/kg body weight per day; context=Maternal toxicity was observed at 2500 mg/kg body weight per day, based on an increase (10%, P < 0.001) in relative kidney weight. [NOAEL (offspring) = 500 mg/kg body weight per day;
WHO/JECFA NOAEL =779 mg/m3 Mouse oral - Developmental toxicity document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=0dce46671b23cb2b; raw_unit=mg/m 3; context=Marshall & Cheng, 1983) of ethylene glycol, derived (Health Canada, 1994) on the basis of a putative NOAEL of 779 mg/m 3 from this study — approximately 156 mg/kg body weight per day 16 — is within the range reported for no-effect levels associated with the occurrence of developmental changes in mice administered the substance orally by gavage (Neeper-Bradley et al., 1995) or t
WHO/JECFA NOAEL =1000 mg/kg bw/day Rat oral - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=cb6849e8d0a9fa43; raw_unit=mg/kg body weight per day; context=NOAEL (maternal) = 1000 mg/kg body weight per day] Other oral studies conducted in rats (Price et al., 1985;
WHO/JECFA NOAEL =1500 mg/kg bw/day Mouse oral - Toxicology study document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=f63b958c910d5973; raw_unit=mg/kg body weight per day; context=NOAEL (maternal) = 1500 mg/kg body weight per day] In a study in which sperm counts and motility, histopathology and organ weights in the testes and epididymis, percentage of pregnant females, and number of live and dead implantation sites were examined in CD-1 mice exposed (both sexes) by gavage to 250–2500
WHO/JECFA NOEL =150 mg/kg bw/day Mouse - - Developmental toxicity document_id=cicads_cicads_cicad45; title=Ethylene Glycol: Human Health Aspects (CICADS 45, 2002); path=mirror/documents/cicads/cicads/cicad45.htm; row_hash=5e79bf82a5a463b1; raw_unit=mg/kg body weight per day; context=In the absence of maternal toxicity, developmental effects (i.e., skeletal changes and, at higher doses, malformations) have also been observed at lowest doses in mice (NOEL = 150 mg/kg body weight per day;
WHO/JECFA LOEL =2553 mg/kg bw - - - Toxicology study document_id=cicads_cicads_cicad_22; title=Ethylene glycol: environmental aspects (CICADS); path=mirror/documents/cicads/cicads/cicad_22.htm; row_hash=2cc513a415af85ea; raw_unit=mg/kg body weight; context=A NOEL of 1221 mg/kg body weight and a lowest-observed-effect level (LOEL) of 2553 mg/kg body weight were reported for orally dosed mallard ducks (Anas platyrhynchos) (Stowe et al., 1981).
WHO/JECFA LOEL =2553 mg/kg bw - - - Toxicology study document_id=cicads_cicads_cicad_22; title=Ethylene glycol: environmental aspects (CICADS); path=mirror/documents/cicads/cicads/cicad_22.htm; row_hash=2cc513a415af85ea; raw_unit=mg/kg body weight; context=A NOEL of 1221 mg/kg body weight and a lowest-observed-effect level (LOEL) of 2553 mg/kg body weight were reported for orally dosed mallard ducks (Anas platyrhynchos) (Stowe et al., 1981).
WHO/JECFA NOEL =221 mg/kg bw - oral - Toxicology study document_id=cicads_cicads_cicad_22; title=Ethylene glycol: environmental aspects (CICADS); path=mirror/documents/cicads/cicads/cicad_22.htm; row_hash=2eeb537d1e6a6771; raw_unit=mg/kg; context=La concentración sin efectos observados (NOEL) para patos a los que se administró por vía oral 1 221 mg/kg de peso corporal y las dosis letales notificadas para aves de corral de alrededor de 8 000 mg/kg de peso corporal indican una toxicidad baja para las aves.
WHO/JECFA NOEL =221 mg/kg bw - oral - Toxicology study document_id=cicads_cicads_cicad_22; title=Ethylene glycol: environmental aspects (CICADS); path=mirror/documents/cicads/cicads/cicad_22.htm; row_hash=2eeb537d1e6a6771; raw_unit=mg/kg; context=La concentración sin efectos observados (NOEL) para patos a los que se administró por vía oral 1 221 mg/kg de peso corporal y las dosis letales notificadas para aves de corral de alrededor de 8 000 mg/kg de peso corporal indican una toxicidad baja para las aves.
WHO/JECFA NOEL =1221 mg/kg bw - - - Toxicology study document_id=cicads_cicads_cicad_22; title=Ethylene glycol: environmental aspects (CICADS); path=mirror/documents/cicads/cicads/cicad_22.htm; row_hash=20c58810ddf63c76; raw_unit=mg/kg body weight; context=A NOEL of 1221 mg/kg body weight and a lowest-observed-effect level (LOEL) of 2553 mg/kg body weight were reported for orally dosed mallard ducks (Anas platyrhynchos) (Stowe et al., 1981).
WHO/JECFA NOEL =1221 mg/kg bw - - - Toxicology study document_id=cicads_cicads_cicad_22; title=Ethylene glycol: environmental aspects (CICADS); path=mirror/documents/cicads/cicads/cicad_22.htm; row_hash=20c58810ddf63c76; raw_unit=mg/kg body weight; context=A NOEL of 1221 mg/kg body weight and a lowest-observed-effect level (LOEL) of 2553 mg/kg body weight were reported for orally dosed mallard ducks (Anas platyrhynchos) (Stowe et al., 1981).
NTP ICE acute oral 23 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_652; row=13207; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4000 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_653; row=13206; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4600 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_654; row=13228; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4700 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1238; row=13224; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =5380 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1241; row=13222; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =5890 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1244; row=13221; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =6133 mg/kg bw Rat (Male/Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1246; row=13220; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >6690 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1247; row=13219; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =7000 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1249; row=13218; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =7712 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1251; row=13217; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =7887 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1254; row=13216; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =8120 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1256; row=13212; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =8540 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1258; row=13213; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =9058 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1260; row=13210; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1262; row=13214; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =10017 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1265; row=13208; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =10020 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1267; row=13209; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =10880 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1269; row=13211; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =11300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1271; row=13223; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =13000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1273; row=13226; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <13380 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1276; row=13227; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <13400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1278; row=13215; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =16200 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1280; row=13225; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol; preferred_name=Ethylene glycol; dtxsid=DTXSID8020597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020597; source_file=acute_oral.xlsx
NTP ICE cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer Top dose 2.5 % Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=8711; Record_ID=cancer_3660; Data_Type=In Vivo; Formulation_Name=Ethylene Glycol; Mixture=Chemical; DTXSID=DTXSID8020597; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2.5; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-413; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr413/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020597
NTP ICE cancer Top dose 5 % Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=8715; Record_ID=cancer_3662; Data_Type=In Vivo; Formulation_Name=Ethylene Glycol; Mixture=Chemical; DTXSID=DTXSID8020597; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-413; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr413/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020597
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9154; RecordID=ARPathway2016_490; DatasetName=ARPathway2016; DTXSID=DTXSID8020597; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020597
EPA ToxRefDB v3 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA ToxRefDB v3 LEL =160 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 13 week SUB study_id=5519; toxval_study_source_id=studyid5519_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-urea nitrogen-urea nitrogen|organ weight-kidney-relative to body weight|pathology microscopic-kidney-vacuolization cytoplasmic|pathology microscopic-kidney-inflammation; dose_level=1; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic rat); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =1250 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 13 week SUB study_id=5519; toxval_study_source_id=studyid5519_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-urea nitrogen-urea nitrogen|organ weight-kidney-relative to body weight|pathology microscopic-kidney-crystals|pathology microscopic-kidney-hyperplasia|pathology microscopic-kidney-dilatation|pathology microscopic-kidney-nephropathy|in life observation-body weight-body weight gain|pathology microscopic-kidney-vacuolization cytoplasmic|clinical chemistry-creatinine-creatinine|pathology gross-kidney-irregular surface|pathology microscopic-kidney-thickened|pathology microscopic-kidney-fibrosis|pathology microscopic-kidney-necrosis|in life observation-mortality-mortality|organ weight-thymus-relative to body weight|pathology microscopic-urinary bladder-crystals|pathology microscopic-kidney-regeneration|pathology microscopic-kidney-distended|pathology microscopic-brain-crystals; dose_level=4; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic rat); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =1500 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=6383; toxval_study_source_id=studyid6383_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-degeneration|pathology microscopic-kidney-nephropathy; dose_level=1; study_year=1993; study_citation=(1993) Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. 107-21-1) in B6C3F1 Mice (Feed Studies). NTP TR 413, NIH Pub No. 93-3144.; dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =3000 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=6383; toxval_study_source_id=studyid6383_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-thyroid gland-hyperplasia|pathology microscopic-lung-hyperplasia|pathology microscopic-liver-degeneration; dose_level=2; study_year=1993; study_citation=(1993) Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. 107-21-1) in B6C3F1 Mice (Feed Studies). NTP TR 413, NIH Pub No. 93-3144.; dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =3750 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 13 week SUB study_id=5520; toxval_study_source_id=studyid5520_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-degeneration|pathology microscopic-liver-hyalinization; dose_level=4; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic mouse); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL >7500 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 13 week SUB study_id=5520; toxval_study_source_id=studyid5520_Adult_F0_F_NA; dose_level=5; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic mouse); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL >0 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 13 week SUB study_id=5519; toxval_study_source_id=studyid5519_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-inflammation|pathology microscopic-kidney-vacuolization cytoplasmic|clinical chemistry-urea nitrogen-urea nitrogen|organ weight-kidney-relative to body weight; dose_level=0; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic rat); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =625 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 13 week SUB study_id=5519; toxval_study_source_id=studyid5519_Adult_F0_M_systemic; toxval_effect_list=pathology gross-kidney-irregular surface|clinical chemistry-creatinine-creatinine|pathology microscopic-kidney-necrosis|in life observation-mortality-mortality|in life observation-body weight-body weight gain|pathology microscopic-kidney-thickened|pathology microscopic-kidney-vacuolization cytoplasmic|pathology microscopic-kidney-fibrosis|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-dilatation|pathology microscopic-kidney-regeneration|organ weight-thymus-relative to body weight|pathology microscopic-urinary bladder-crystals|pathology microscopic-kidney-hyperplasia|pathology microscopic-brain-crystals|organ weight-kidney-relative to body weight|pathology microscopic-kidney-crystals|clinical chemistry-urea nitrogen-urea nitrogen|organ weight-kidney-absolute|pathology microscopic-kidney-distended; dose_level=3; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic rat); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =937.5 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=6383; toxval_study_source_id=studyid6383_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-degeneration|pathology microscopic-lung-hyperplasia|pathology microscopic-thyroid gland-hyperplasia; dose_level=1; study_year=1993; study_citation=(1993) Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. 107-21-1) in B6C3F1 Mice (Feed Studies). NTP TR 413, NIH Pub No. 93-3144.; dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =1875 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 13 week SUB study_id=5520; toxval_study_source_id=studyid5520_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-degeneration|pathology microscopic-liver-hyalinization; dose_level=3; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EG Subchronic mouse); dsstox_substance_id=DTXSID8020597; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB ATSDR MRLs 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ATSDR MRLs BMDL (10) =75.56 mg/kg bw/day Mouse oral short-term (developmental); 10 days developmental LONG_REF=Neeper-Bradley TL, Tyl RW, Fisher LC, et al. 1995. Determination of a no-observed-effect level for developmental toxicity of ethylene glycol administered by gavage to CD rats and CD-1 mice. Fundam Appl Toxicol 27:121-130. ; Tyl RW. 1989. Developmental toxicity evaluation of ethylene glycol administrated by gavage to CD-1 mice: Determination of a \"no-observed-effect-level\" (NOEL). Bushy Run Research Center, CMA Project Report 51-591.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp96.pdf; TOXICOLOGICAL_EFFECT=developmental; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ATSDR MRLs_dup_-_15447604_15447605:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c04c1e35a86658e250a5814140d745f3
ToxValDB ATSDR MRLs MRL =0.8 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=developmental in male/female mice; STUDY_GROUP=ATSDR MRLs_dup_-_15447074_15447075:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e21e9220217954c167232c4891e82186
ToxValDB ATSDR MRLs MRL =2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs:15447073:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_19c8016b24295ab4bafd4b4231fb6ddd
ToxValDB ATSDR MRLs NOAEL =23 mg/m3 Human inhalation short-term; 30 days clinical LONG_REF=Wills JH, Coulston F, Harris ES, et al. 1974. Inhalation of aerosolized ethylene glycol by man. Clin Toxicol 7(5):463-476.; TITLE=Inhalation of aerosolized ethylene glycol by man; AUTHOR=Wills JH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp96.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447603:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f0e7d413b26f7be301a9f1b4f7f8ced5
ToxValDB Alaska DEC 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Alaska DEC RfD =1 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445763:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=f0a9ebd14ef392b877ef162a82ebf312
ToxValDB Alaska DEC RfD =1 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445763:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=f0a9ebd14ef392b877ef162a82ebf312
ToxValDB Alaska DEC RfD =2 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445764:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=08eac0e59634a07d4fb86ce2280e1cfc
ToxValDB Alaska DEC RfD =2 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445764:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=08eac0e59634a07d4fb86ce2280e1cfc
ToxValDB Cal OEHHA REL derivations 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Cal OEHHA REL derivations NOAEL =50.7716 mg/m3 Human inhalation short-term; 30 days clinical LONG_REF=Wills JH, Coulston F, Harris ES, McChesney EW, Russell JC, and Serrone DW. 1974. Inhalation of aerosolized ethylene glycol by man. Clin. Toxicol. 7:463-476; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=respiratory tract irritation; STUDY_GROUP=Cal OEHHA REL derivations:15952060:M:-volunteer prisoners; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a07d8e247f8cf2a3a9f55b0df94dadd
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =81234.6 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=DOE Protective Action Criteria:15515427:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6596c875a44ef6014de889dd88d3f3b0
ECHA 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =500 mg/kg bw/day Rat oral chronic; 16 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19636/7/6/2?documentUUID=31ad89a7-9ebd-4a81-ab4e-ed2959874aa0; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=kidney: histopathology: non-neoplastic|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834256_15834257:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a095ac529703776e56f266c3e336985f
ECHA LOAEL =750 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6cd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821242_15821322_15821492:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2efbdcae0ef9d16a120e29e95d175e99
ECHA LOAEL =1250 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821890:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3524a9411e303711aa84b1d50ada069f
ECHA LOAEL =3000 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b48b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/8?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=liver: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15816422:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a3bfa7c56ae3732745fbab259f3952b
ECHA NOAEC =150 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ed15; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15821253:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1529038c444fad89282b56f77072a375
ECHA NOAEC =1000 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ed15; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15822576:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebe9f49ca1a4ef7bedd55cbfdb0d40ab
ECHA NOAEL =78 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cc0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/8?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15816072:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a3f9deb4c05ec7bd6f321e565d7ca249
ECHA NOAEL =150 mg/kg bw/day Rat oral chronic; 16 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19636/7/6/2?documentUUID=31ad89a7-9ebd-4a81-ab4e-ed2959874aa0; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=kidney: histopathology: non-neoplastic|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834256_15834257:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3eadd9fb54b033d64d1d1da0ca5ada94
ECHA NOAEL ~200 mg/kg bw/day Rat oral subchronic; 33 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0da3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/6/2?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=kidney: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15839654:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03f748192ed709a9c5b18f2c9e153ebb
ECHA NOAEL =250 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820572_15821425:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c63e7eed5abd03aa1c24ef7a4b166270
ECHA NOAEL =500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6d0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820572_15821425:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f71f90e674e4a985fcded11276ca6214
ECHA NOAEL =750 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6cd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822566_15822638_15822807_15822920:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_557421609be22c6ded5d8e90072f1bae
ECHA NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15820734:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2bc5618584dd19f473c47f65b1dd1f61
ECHA NOAEL =1500 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b48b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/8?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=liver: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816421_15817429:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3d8e3b4aff6b813137c555b83e7d698e
ECHA NOAEL =2000 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3f3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15820610:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_79fc7026b1846595371d3ba9a5664cc7
ECHA NOAEL ~2200 mg/kg bw/day Dog dermal short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e7ce4b096bca8779dd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/6/4?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=kidney; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826527_15826902_15826903:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b66cf78ac55693d7cf500111f1a617e0
ECHA NOAEL =2312.5 mg/kg bw/day Mouse oral chronic; 96 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0da1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/6/2?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15831784:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e2a22cbd8a9d2c00a1aebba4d1418a05
ECHA NOAEL =3549 mg/kg bw/day Mouse dermal - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24be4b0a7c65d2326ff; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25768/7/9/3?documentUUID=5f553d3c-b07d-4ee2-9807-9d21b7e135b6; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821208_15821743:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c25f97efdf27668049d20359010a9bd8
ECHA NOAEL ~4400 mg/kg bw/day Dog dermal short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d82e4b096bca8775fd0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/6/4?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15826186:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f00f266eb0af3ae5222645da0c1fbd6b
ECHA NOEL =150 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821242_15821322_15821492:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_383610b1fe2505dbbdc41ffce59ca99b
ECHA NOEL =1500 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15973/7/9/3?documentUUID=7143f69a-0a4c-423c-bda2-4dfeb3b6bb21; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822566_15822638_15822807_15822920:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5bbb955d70e5e15a2dd6ac52de959de7
ToxValDB ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =11090 mg/kg bw/day Mouse oral short-term (developmental); 8 days reproduction developmental LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight|Growth: Weight gain|Mortality: Survival|Reproduction: Progeny counts/numbers|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15611933:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=20dfb908fe4a0a5d6fdd5340a9d723ff
ToxValDB ECOTOX NOEL =1.5 % Mouse oral chronic; 361 days chronic LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15607789:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=05a3a72c795f29a6e15eb52eefb15dc2
ToxValDB EPA HWIR 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EPA HWIR NOAEL =67 mg/m3 Human inhalation short-term; 30 days clinical LONG_REF=Wills, J.H., F. Coulston, E.S. Harris, et al. 1974. Inhalation of aerosolized ethylene glycol by man. Clin Toxicol 7:463-476.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Throat and upper respiratory tract irritation; STUDY_GROUP=EPA HWIR:15952205:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c98feb8610e54436a02dc1efe90c3744
ToxValDB EPA HWIR RfC =0.6 mg/m3 Human inhalation - toxicity value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; STUDY_GROUP=EPA HWIR:15952204:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c45de35509f3e2c583f4fc51e1f3f177
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =35 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631960:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f06c8a5f3d3aee2956afe4b4bcded061
ToxValDB IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB IRIS LOAEL =1000 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=DePass, L.R., R.H. Garman, M.D. Woodside, et al. 1986a. Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice. Fund. Appl. Toxicol. 7: 547-565.; TITLE=Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice; AUTHOR=DePass, L.R., R.H. Garman, M.D. Woodside, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=238; TOXICOLOGICAL_EFFECT=kidney toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644528_15644536:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_27614f5d47095357c1d9d5c10ff2982e
ToxValDB IRIS NOEL =200 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=DePass, L.R., R.H. Garman, M.D. Woodside, et al. 1986a. Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice. Fund. Appl. Toxicol. 7: 547-565.; TITLE=Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice; AUTHOR=DePass, L.R., R.H. Garman, M.D. Woodside, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=238; TOXICOLOGICAL_EFFECT=kidney toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644528_15644536:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_781f7fd93a7280e7da550b2700b14cb0
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Pennsylvania DEP ToxValues RfC =0.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650117:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8adc35cd927daefe7782f5f5d2a662b7
ToxValDB TX TCEQ 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB TX TCEQ LOAEL =12 mg/m3 Rat inhalation subchronic; 90 days subchronic LONG_REF=Coon, R.A., Jones, R.A., Jenkins Jr., L.J., and Siegel, J. 1970. Animal inhalation studies on ammonia, ethylene glycol, formaldehyde, dimethylamine, and ethanol. Toxicology and Applied Pharmacology. 16: 646-655.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b09; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/eg.pdf; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=Ocular irritation and nonspecific inflammatory changes in the lungs; STUDY_GROUP=TX TCEQ:15954444:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d27d3ae72f2e00ddfb1b6f85b0e52681
ToxValDB TX TCEQ LOAEL =140 mg/m3 Human inhalation acute; 20 hours clinical LONG_REF=Wills, J.H., Coulston, F., Harris, E.S., McChesney, E.W., Russell, J.C., and Serrone, D.M. 1974. Inhalation of aerosolized ethylene glycol by man. Clinical Toxicology. 7(5): 463-476; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b09; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/eg.pdf; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=Respiratory irritation; STUDY_GROUP=TX TCEQ:15954449:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55d86e61d7faf623940800c2cc411a30
ToxValDB ToxRefDB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ToxRefDB LEL =160 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EG Subchronic rat); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5519; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-kidney-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB:15709434:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38ed22707829c063cdd1ce87fec1d652
ToxValDB ToxRefDB LEL =1250 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EG Subchronic rat); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5519; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-hyperplasia|systemic: clinical chemistry-creatinine-creatinine|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: organ weight-kidney-relative to body weight|systemic: pathology gross-kidney-irregular surface|systemic: pathology microscopic-kidney-crystals|systemic: pathology microscopic-kidney-dilatation|systemic: pathology microscopic-kidney-nephropathy|systemic: organ weight-thymus-relative to body weight|systemic: pathology microscopic-urinary bladder-crystals|systemic: pathology microscopic-kidney-distended|systemic: pathology microscopic-kidney-thickened|systemic: pathology microscopic-kidney-fibrosis|systemic: pathology microscopic-brain-crystals|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-kidney-regeneration|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709435_15709436_15709437_15709438:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d528afec0a8a2425a17eb9c97a72f7e
ToxValDB ToxRefDB LEL =3750 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EG Subchronic mouse); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5520; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-hyalinization|systemic: pathology microscopic-liver-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709443_15709444_15709445_15709446:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6aff81eea84057cc5d2af5e8797074db
ToxValDB ToxRefDB LEL >7500 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EG Subchronic mouse); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5520; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ToxRefDB_dup_-_15709439_15709440_15709441_15709442:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_181051183e3e9a608981a2f90ef5844a
ToxValDB ToxRefDB NEL =625 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EG Subchronic rat); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5519; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-brain-crystals|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-kidney-dilatation|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-kidney-regeneration|systemic: organ weight-kidney-relative to body weight|systemic: pathology gross-kidney-irregular surface|systemic: pathology microscopic-kidney-crystals|systemic: in life observation-mortality-mortality|systemic: organ weight-thymus-relative to body weight|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: clinical chemistry-creatinine-creatinine|systemic: pathology microscopic-urinary bladder-crystals|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-kidney-hyperplasia|systemic: pathology microscopic-kidney-distended|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-thickened|systemic: pathology microscopic-kidney-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-fibrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709435_15709436_15709437_15709438:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2cd02176daa94026d6a04ed61f5060b7
ToxValDB ToxRefDB NEL =937.5 mg/kg bw/day Mouse oral chronic; 2 years chronic LONG_REF=(1993) Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. 107-21-1) in B6C3F1 Mice (Feed Studies). NTP TR 413, NIH Pub No. 93-3144.; TITLE=Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. 107-21-1) in B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6383; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-lung-hyperplasia|systemic: pathology microscopic-thyroid gland-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711572_15711573:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fbdd120f12063d1c1055d4bec975a6b
ToxValDB ToxRefDB NEL =1875 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EG Subchronic mouse); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5520; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-liver-hyalinization; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709443_15709444_15709445_15709446:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bbb817bba993c5cc594e0d50fe6aba90
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier FC72KVT52F UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FC72KVT52F"}
openFDA substances FDA UNII substance identifier FC72KVT52F UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FC72KVT52F"}
openFDA substances FDA UNII substance identifier FC72KVT52F UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FC72KVT52F"}
openFDA substances FDA UNII substance identifier FC72KVT52F UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FC72KVT52F"}