GLYCOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
4 study endpoints found for GLYCOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 150 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| LOAEL | 300 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 12500 ppm | oral | mouse | Subchronic | COSMOS_DB |
| LOAEL | 25000 ppm | oral | mouse | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
GLYCOL is listed in the EU CosIng database with functions: Humectant, Solvent, Viscosity Controlling It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is GLYCOL safe in cosmetics?
GLYCOL is listed in the EU CosIng database with functions: Humectant, Solvent, Viscosity Controlling It is permitted in the EU without specific restrictions. The EU classifies GLYCOL as "Permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is GLYCOL allowed in the EU?
GLYCOL EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does GLYCOL do in cosmetics?
GLYCOL functions as: Humectant, Solvent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 107-21-1.
What is the NOAEL for GLYCOL?
The NOAEL (No Observed Adverse Effect Level) for GLYCOL is 150 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is GLYCOL classified as hazardous under GHS?
GLYCOL carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed May cause damage to kidneys and central nervous system. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check GLYCOL compliance across multiple jurisdictions:
Related Ingredients
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