NOAEL Studies Cosmetic Ingredient

Glyoxal NOAEL Studies

INCI: GLYOXAL

CAS: 107-22-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL <50 mg/kg/day rat oral - developmental toxicity 30; 6; 9, p.7
CIR Safety Assessment NOAEL =100 mg/kg/day rat oral 28-day oral toxicity 28; 100; 300, p.12
CIR Safety Assessment NOAEL >300 mg/kg/day rabbit oral - developmental toxicity 300; 150; 200, 800, p.7
WHO/JECFA 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA LOAEL =107 mg/kg bw/day Rat oral 90-day Subchronic toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=fb285543b88d62dc; raw_unit=mg/kg body weight per day; context=In a 90-day drinking-water study in rats examining more sensitive end-points, the lowest tested dosage of 107 mg/kg body weight per day (99% glyoxal) was given as the LOAEL for serum clinical parameters (Ueno et al., 1991a).
WHO/JECFA NOAEL =125 mg/kg bw/day Rat oral 90-day Subchronic toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=8e0704ed31771dee; raw_unit=mg/kg body weight per day; context=The 90-day feeding of glyoxal to rats resulted in a NOAEL of 125 mg/kg body weight per day (dosage corresponding to 100% glyoxal).
WHO/JECFA NOAEL ~40 mg/kg bw Rat oral 90-day Subchronic toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=38d9aca49db1e4eb; raw_unit=mg/kg body weight; context=If not, the NOAEL would be about 40 mg/kg body weight adjusted to 100% glyoxal.) 8.3 Medium-term exposure In a 90-day feeding study, Wistar rats (10 males and 10 females per dose group) were exposed to glyoxal (40% preparation).
WHO/JECFA NOAEL ~100 mg/kg bw/day - oral - Toxicology study document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=84419a8e6baf9cb5; raw_unit=mg/kg body weight per day; context=From studies on oral exposure, the NOAEL seems to be about 100 mg/kg body weight per day (adjusted to 100% glyoxal).
WHO/JECFA NOAEL =25 mg/kg bw - - lifetime Chronic toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=f55d03ff8950e4a7; raw_unit=mg/kg body weight; context=The use of the lifetime extrapolation uncertainty factor (factor of 5) is also justified on the basis of the 125 mg/kg body weight LOAEL with wide dose spacing to a NOAEL of 25 mg/kg body weight (BASF & Clariant, 2000).
WHO/JECFA NOAEL =125 mg/kg bw Rat - - Toxicology study document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=9ede73a4cd303453; raw_unit=mg/kg; context=Pour d'autres rats qui en avaient reçu pendant 90 jours dans leur alimentation, la NOAEL s'est révélée égale à 125 mg/kg de poids corporel par jour (dose correspondant à 100 % de glyoxal).
WHO/JECFA NOEL >8.9 mg/m3 Rat inhalation 29-day Inhalation toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=7b72322d14d89674; raw_unit=mg/m 3; context=29-day) inhalation exposure of rats to glyoxal showed a no-observed-effect level (NOEL) of 0.6 mg/m 3 (nominal concentration was 0.4 mg/m 3 ) for local effects in the larynx and a NOEL of >8.9 mg/m 3 (nominal concentration was 10 mg/m 3 ) for systemic effects (examination of body weight, haematological and biochemical parameters, urine analysis, macroscopic and histological examination).
WHO/JECFA NOEL =0.6 mg/m3 Rat inhalation 29-day Inhalation toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=16ad53bb58358bfc; raw_unit=mg/m 3; context=Taking the 29-day inhalation study in rats exposed to glyoxal, which showed a NOEL of 0.6 mg/m 3 for local effects in the larynx, and using uncertainty factors of 10 for interspecies differences and 10 for interindividual differences, a tolerable concentration of 6 ug/m 3 for local effects in the larynx for short-term exposure was estimated.
WHO/JECFA NOEL >115 mg/kg bw/day Dog oral 90-day Subchronic toxicity document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=a1850408a020af8c; raw_unit=mg/kg body weight per day; context=The NOEL for 90-day feeding of glyoxal to dogs was >115 mg/kg body weight per day (dosage corresponding to 100% glyoxal) (Mellon Institute, 1966).
WHO/JECFA NOEL =6 mg/m3 Human; Rat - - Toxicology study document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=820e25519f9fffa5; raw_unit=mg/m 3; context=Des études au cours desquelles on a fait inhaler du glyoxal à des rats pendant une courte période (29 jours), montrent que la dose sans effet observable au niveau du larynx (NOEL) est de 0,6 mg/m 3 (concentration nominale égale à 0,4 mg/m 3 ), la dose sans effets généraux observables (contrôle du poids corporel, des paramètres hématologiques et biochimiques, analyse d'urine, examen macroscopique et histologique) étant supérieure à 8.9 mg/m 3 (concentrat
WHO/JECFA NOEL =9 mg/m3 Human - - Toxicology study document_id=cicads_cicads_cicad57; title=Glyoxal (Cicads 57, 2004); path=mirror/documents/cicads/cicads/cicad57.htm; row_hash=9a6acd6607a276a1; raw_unit=mg/m 3; context=ción se puso de manifiesto una concentración sin efectos observados (NOEL) de 0,6 mg/m 3 (la concentración nominal fue de 0,4 mg/m 3 ) para los efectos locales en la laringe y una NOEL de >8,9 mg/m 3 (la concentración nominal fue de 10 mg/m 3 ) para los efectos sistémicos (examen del peso corporal, parámetros hematológicos y bioquímicos, análisis de orina, examen macroscópico e histológico).
NTP ICE acute inhalation 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 2.44 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2904; Record_ID=acute_inhalation_532; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.44; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16112/7/3/3/?documentUUID=850f84ca-6a81-47d6-8559-881943a66d05; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE acute inhalation LC50 2.47 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2905; Record_ID=acute_inhalation_533; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.47; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16112/7/3/3/?documentUUID=850f84ca-6a81-47d6-8559-881943a66d05; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE acute inhalation LC50 >11.56 mg/L - Inhalation Duration=7 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2906; Record_ID=acute_inhalation_534; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=11.56; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16112/7/3/3/?documentUUID=aad62e23-9cea-42dc-b275-bc394f7707f0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE acute inhalation LC50 2.41 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2907; Record_ID=acute_inhalation_2748; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.41; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE acute oral 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =4290 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1292; row=8882; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =7070 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1294; row=8883; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1282; row=8884; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =762 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1285; row=8885; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1287; row=8886; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1289; row=8887; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2960 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1290; row=8888; data_type=In Vivo; mixture=Chemical; chemical_name=Glyoxal; preferred_name=Glyoxal; dtxsid=DTXSID5025364; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025364; source_file=acute_oral.xlsx
NTP ICE skin sensitization 90 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 286.7 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2029; Record_ID=skin_sensitization_invitro_509; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=286.7; Reported_Response_Unit=ug/mL; Response=286.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization CD86, EC150 27.998 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8269; Record_ID=skin_sensitization_invitro_2292; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=482.4259132; Reported_Response_Unit=uM; Conversion_Factor_Value=58.036; Conversion_Factor_Source=EPA Dashboard; Converted_Response=27.998; Converted_Response_Unit=ug/mL; Response=27.998; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization CD86, EC150 32.63 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8534; Record_ID=skin_sensitization_invitro_2354; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=32.63; Reported_Response_Unit=ug/mL; Response=32.63; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization CV70 92.79 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8536; Record_ID=skin_sensitization_invitro_2354; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=U-SENS; Endpoint=CV70; Reported_Response=92.79; Reported_Response_Unit=ug/mL; Response=92.79; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization CV75 396 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2031; Record_ID=skin_sensitization_invitro_509; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=h-CLAT; Endpoint=CV75; Reported_Response=396; Reported_Response_Unit=ug/mL; Response=396; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3229; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Concentration, one positive response 0.4167 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3225; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.4167; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Depletion Cys 56.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1084; Record_ID=skin_sensitization_invitro_295; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=56.5; Reported_Response_Unit=%; Response=56.5; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Depletion Cys 68.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1091; Record_ID=skin_sensitization_invitro_296; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=68.2; Reported_Response_Unit=%; Response=68.2; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Depletion Lys 67.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1082; Record_ID=skin_sensitization_invitro_295; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=67.8; Reported_Response_Unit=%; Response=67.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Depletion Lys 26.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1089; Record_ID=skin_sensitization_invitro_296; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=26.7; Reported_Response_Unit=%; Response=26.7; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Depletion Lys + Cys 62.15 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1086; Record_ID=skin_sensitization_invitro_295; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=62.15; Reported_Response_Unit=%; Response=62.15; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Depletion Lys + Cys 47 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1093; Record_ID=skin_sensitization_invitro_296; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=47; Reported_Response_Unit=%; Response=47; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 87 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4467; Record_ID=skin_sensitization_invitro_1030; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=87; Reported_Response_Unit=uM; Response=87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 88.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4468; Record_ID=skin_sensitization_invitro_1031; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=88.6; Reported_Response_Unit=uM; Response=88.6; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 89.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4469; Record_ID=skin_sensitization_invitro_1032; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=89.1; Reported_Response_Unit=uM; Response=89.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 89.12 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4470; Record_ID=skin_sensitization_invitro_1025; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=89.12; Reported_Response_Unit=uM; Response=89.12; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 91.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4471; Record_ID=skin_sensitization_invitro_1033; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=91.7; Reported_Response_Unit=uM; Response=91.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 95.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4472; Record_ID=skin_sensitization_invitro_1029; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=95.6; Reported_Response_Unit=uM; Response=95.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 100.92 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4540; Record_ID=skin_sensitization_invitro_1046; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=100.92; Reported_Response_Unit=uM; Response=100.92; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 107.53 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4541; Record_ID=skin_sensitization_invitro_1047; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=107.53; Reported_Response_Unit=uM; Response=107.53; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 115.89 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4543; Record_ID=skin_sensitization_invitro_1045; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=115.89; Reported_Response_Unit=uM; Response=115.89; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 116.87 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4545; Record_ID=skin_sensitization_invitro_1041; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=116.87; Reported_Response_Unit=uM; Response=116.87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 120 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4547; Record_ID=skin_sensitization_invitro_1028; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=120; Reported_Response_Unit=uM; Response=120; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 123.92 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4549; Record_ID=skin_sensitization_invitro_1042; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=123.92; Reported_Response_Unit=uM; Response=123.92; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 127.41 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4551; Record_ID=skin_sensitization_invitro_1035; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=127.41; Reported_Response_Unit=uM; Response=127.41; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 127.64 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4553; Record_ID=skin_sensitization_invitro_1040; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=127.64; Reported_Response_Unit=uM; Response=127.64; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 130.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4555; Record_ID=skin_sensitization_invitro_1037; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=130.5; Reported_Response_Unit=uM; Response=130.5; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 131.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4557; Record_ID=skin_sensitization_invitro_1038; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=131.19999999999999; Reported_Response_Unit=uM; Response=131.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 134.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4559; Record_ID=skin_sensitization_invitro_1026; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=134.1; Reported_Response_Unit=uM; Response=134.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 140.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4561; Record_ID=skin_sensitization_invitro_1036; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=140.80000000000001; Reported_Response_Unit=uM; Response=140.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 146.06 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4563; Record_ID=skin_sensitization_invitro_1039; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=146.06; Reported_Response_Unit=uM; Response=146.06; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 169.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4565; Record_ID=skin_sensitization_invitro_1043; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=169.1; Reported_Response_Unit=uM; Response=169.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 175.14 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4567; Record_ID=skin_sensitization_invitro_1044; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=175.14; Reported_Response_Unit=uM; Response=175.14; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 228.98 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4570; Record_ID=skin_sensitization_invitro_1049; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=228.98; Reported_Response_Unit=uM; Response=228.98; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 24.58 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4572; Record_ID=skin_sensitization_invitro_1034; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=24.58; Reported_Response_Unit=uM; Response=24.58; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 77 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4574; Record_ID=skin_sensitization_invitro_1027; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=77; Reported_Response_Unit=uM; Response=77; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 80.41 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4576; Record_ID=skin_sensitization_invitro_1048; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=80.41; Reported_Response_Unit=uM; Response=80.41; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC1.5 <180.84 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7604; Record_ID=skin_sensitization_invitro_1843; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=180.84; Reported_Response_Unit=uM; Response=180.84; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC3 307.8 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4473; Record_ID=skin_sensitization_invitro_1025; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=307.80500000000001; Reported_Response_Unit=uM; Response=307.8; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization EC3 1.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13285; Record_ID=skin_sensitization_invivo_3380; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=LLNA; Endpoint=EC3; Response=1.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 364.57 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4474; Record_ID=skin_sensitization_invitro_1034; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=364.57; Reported_Response_Unit=uM; Response=364.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 523.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4475; Record_ID=skin_sensitization_invitro_1027; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=523.20000000000005; Reported_Response_Unit=uM; Response=523.2; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 573.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4476; Record_ID=skin_sensitization_invitro_1035; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=573.82000000000005; Reported_Response_Unit=uM; Response=573.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 594.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4477; Record_ID=skin_sensitization_invitro_1036; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=594.66999999999996; Reported_Response_Unit=uM; Response=594.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 607.13 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4478; Record_ID=skin_sensitization_invitro_1037; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=607.13; Reported_Response_Unit=uM; Response=607.13; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 610.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4479; Record_ID=skin_sensitization_invitro_1026; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=610.5; Reported_Response_Unit=uM; Response=610.5; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 630.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4480; Record_ID=skin_sensitization_invitro_1038; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=630.17999999999995; Reported_Response_Unit=uM; Response=630.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 677.86 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4481; Record_ID=skin_sensitization_invitro_1025; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=677.86; Reported_Response_Unit=uM; Response=677.86; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 684.61 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4482; Record_ID=skin_sensitization_invitro_1039; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=684.61; Reported_Response_Unit=uM; Response=684.61; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 689.79 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4483; Record_ID=skin_sensitization_invitro_1040; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=689.79; Reported_Response_Unit=uM; Response=689.79; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 693.99 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4484; Record_ID=skin_sensitization_invitro_1041; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=693.99; Reported_Response_Unit=uM; Response=693.99; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 696.02 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4485; Record_ID=skin_sensitization_invitro_1042; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=696.02; Reported_Response_Unit=uM; Response=696.02; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 700.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4486; Record_ID=skin_sensitization_invitro_1043; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=700.4; Reported_Response_Unit=uM; Response=700.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 704.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4487; Record_ID=skin_sensitization_invitro_1044; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=704.8; Reported_Response_Unit=uM; Response=704.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 721.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4488; Record_ID=skin_sensitization_invitro_1028; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=721.9; Reported_Response_Unit=uM; Response=721.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 785.71 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4489; Record_ID=skin_sensitization_invitro_1045; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=785.71; Reported_Response_Unit=uM; Response=785.71; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 >800 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4490; Record_ID=skin_sensitization_invitro_1029; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=800; Reported_Response_Unit=uM; Response=800; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization IC50 >450 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7674; Record_ID=skin_sensitization_invitro_1843; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=450; Reported_Response_Unit=uM; Response=450; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 10.93 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4495; Record_ID=skin_sensitization_invitro_1034; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=10.93; Reported_Response_Unit=Unitless; Response=10.93; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 100.866 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4496; Record_ID=skin_sensitization_invitro_1036; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=100.866; Reported_Response_Unit=Unitless; Response=100.866; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 116.078 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4497; Record_ID=skin_sensitization_invitro_1049; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=116.078; Reported_Response_Unit=Unitless; Response=116.078; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 132.82 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4498; Record_ID=skin_sensitization_invitro_1046; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=132.82; Reported_Response_Unit=Unitless; Response=132.82; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 14.5 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4499; Record_ID=skin_sensitization_invitro_1027; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=14.5; Reported_Response_Unit=Unitless; Response=14.5; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 14.67 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4500; Record_ID=skin_sensitization_invitro_1035; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=14.667999999999999; Reported_Response_Unit=Unitless; Response=14.67; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 17.881 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4501; Record_ID=skin_sensitization_invitro_1039; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.881; Reported_Response_Unit=Unitless; Response=17.881; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 176.768 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4504; Record_ID=skin_sensitization_invitro_1048; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=176.768; Reported_Response_Unit=Unitless; Response=176.768; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 195 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4506; Record_ID=skin_sensitization_invitro_1029; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=195; Reported_Response_Unit=Unitless; Response=195; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 21.802 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4508; Record_ID=skin_sensitization_invitro_1038; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=21.802; Reported_Response_Unit=Unitless; Response=21.802; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 23.63 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4510; Record_ID=skin_sensitization_invitro_1030; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.632000000000001; Reported_Response_Unit=Unitless; Response=23.63; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 26.343 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4512; Record_ID=skin_sensitization_invitro_1042; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=26.343; Reported_Response_Unit=Unitless; Response=26.343; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 275.5 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4514; Record_ID=skin_sensitization_invitro_1047; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=275.46199999999999; Reported_Response_Unit=Unitless; Response=275.5; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 28.19 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4516; Record_ID=skin_sensitization_invitro_1025; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=28.19; Reported_Response_Unit=Unitless; Response=28.19; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 3.521 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4518; Record_ID=skin_sensitization_invitro_1032; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.5209999999999999; Reported_Response_Unit=Unitless; Response=3.521; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 31.384 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4520; Record_ID=skin_sensitization_invitro_1045; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=31.384; Reported_Response_Unit=Unitless; Response=31.384; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 4.27 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4522; Record_ID=skin_sensitization_invitro_1031; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=4.2699999999999996; Reported_Response_Unit=Unitless; Response=4.27; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 58.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4524; Record_ID=skin_sensitization_invitro_1028; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=58.3; Reported_Response_Unit=Unitless; Response=58.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 64.68 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4526; Record_ID=skin_sensitization_invitro_1040; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=64.685000000000002; Reported_Response_Unit=Unitless; Response=64.68; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 66.67 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4528; Record_ID=skin_sensitization_invitro_1044; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=66.665000000000006; Reported_Response_Unit=Unitless; Response=66.67; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 67.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4530; Record_ID=skin_sensitization_invitro_1026; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=67.099999999999994; Reported_Response_Unit=Unitless; Response=67.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 69.7 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4532; Record_ID=skin_sensitization_invitro_1043; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=69.7; Reported_Response_Unit=Unitless; Response=69.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 78.65 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4534; Record_ID=skin_sensitization_invitro_1037; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=78.650999999999996; Reported_Response_Unit=Unitless; Response=78.65; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 78.82 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4536; Record_ID=skin_sensitization_invitro_1041; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=78.820999999999998; Reported_Response_Unit=Unitless; Response=78.82; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 81.32 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4539; Record_ID=skin_sensitization_invitro_1033; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=81.322999999999993; Reported_Response_Unit=Unitless; Response=81.32; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Imax 4.643 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7577; Record_ID=skin_sensitization_invitro_1843; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=LuSens; Endpoint=Imax; Reported_Response=4.6432523; Reported_Response_Unit=Unitless; Response=4.643; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Incidence of positive responses 100 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3189; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=100; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Induction dose per skin area 6207 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3188; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6207; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 310.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3231; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=310.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Induction dose per skin area, one positive response 258.6 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3227; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=258.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
NTP ICE skin sensitization Relative reliability score 1 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3233; Record_ID=skin_sensitization_invivo_821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025364; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025364; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025364
SCCS Opinion 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.4 - rat inhalation 29 days NOAEL study p.24
SCCS Opinion NOAEL =5 mg/kg bw rat oral - NOAEL study p.38
SCCS Opinion NOAEL =24 - - - - NOAEL study p.24
SCCS Opinion NOAEL =25 mg/kg bw - - prenatal repeated dose toxicity p.46
SCCS Opinion NOAEL =40 % rat oral 90-day repeated dose toxicity p.24
SCCS Opinion NOAEL =40 mg/kg bw/day rat oral 28-day NOAEL study p.52
SCCS Opinion NOAEL =100 mg/kg bw/day - - - NOAEL study p.20
SCCS Opinion NOAEL =100 mg/kg bw rat oral 28 day NOAEL study p.49
SCCS Opinion NOAEL =107 mg/kg bw - - - NOAEL study Ref.: Ueno et al, p.22
SCCS Opinion NOAEL =115 mg/kg bw rat oral 90-day repeated dose toxicity p.24
SCCS Opinion NOAEL =125 mg/kg bw - - prenatal repeated dose toxicity p.46
SCCS Opinion NOAEL =127 mg/kg bw/day rat - 28-day repeated dose toxicity p.52
SCCS Opinion NOAEL =132 mg/kg bw rat oral 90 days NOAEL study p.24
SCCS Opinion NOAEL =881 - rabbit oral Developmental developmental toxicity p.44
SCCS Opinion NOAEL =1000 mg/kg bw rat oral 90-day repeated dose toxicity p.24
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =2000 mg/L Rat oral short-term; 30 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb12e4b0a7c65d224a7c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/6/2?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15833149:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ab57b0aeee4e5251c7e811ba0a70a00
ECHA LOAEL =250 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae07e4b0a7c65d1c7372; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/6/2?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847674_15847781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e156e3338ee0840815eee0d876fe837
ECHA NOAEL =115 mg/kg bw/day Dog oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae07e4b0a7c65d1c7366; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/6/2?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15836993:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b598407e42c1a8164549ebe3619c0299
ECHA NOAEL =125 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae07e4b0a7c65d1c7372; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/6/2?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847674_15847781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3fa889d724726de22bd6c1e90d4e1e9d
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =0.04 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632420_15632421:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1813c5facde93a5c1b3ce6d8c1fffa3f
ToxValDB GESTIS DNEL DNEL systemic =2.96 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632420_15632421:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccea26cddf67b4b1c548311529c49303
Regulatory source 29 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 0.4 - rat inhalation 29 days - p.24
Regulatory source - 5 mg/kg bw rat oral - - p.38
Regulatory source - 24 - - - - - p.24
Regulatory source - 24 - rat inhalation 29 days - p.24
Regulatory source - 40 mg/kg bw/day rat oral 28-day - p.52
Regulatory source - 40 % rat - 28-day - p.55
Regulatory source - 40 mg/kg bw/day rat - 28-day - p.55
Regulatory source - 100 mg/kg bw/day - - - - p.20
Regulatory source - 100 mg/kg bw rat oral 28 day - p.49
Regulatory source - 100 mg/kg bw rat oral 28 days - p.24
Regulatory source - 107 mg/kg bw - - - - p.22
Regulatory source - 107 mg/kg bw rat oral 90 days - p.24
Regulatory source - 115 mg/kg bw rat oral 90 days - p.24
Regulatory source - 115 mg/kg bw dog oral 90 days - p.24
Regulatory source - 132 mg/kg bw rat oral 90 days - p.24
Regulatory source carcinogenicity 40 % rat oral 28-day carcinogenicity p.52
Regulatory source developmental toxicity 40 % rat oral developmental developmental toxicity p.44
Regulatory source developmental toxicity 881 - rabbit oral Developmental developmental toxicity p.44
Regulatory source genotoxicity 5 mg/kg bw rat oral - genotoxicity p.39
Regulatory source repeated dose toxicity 25 mg/kg bw - - prenatal repeated dose toxicity p.46
Regulatory source repeated dose toxicity 25 mg/kg bw - - 90 days repeated dose toxicity p.46
Regulatory source repeated dose toxicity 25 mg/kg bw rat - 90-day repeated dose toxicity p.52
Regulatory source repeated dose toxicity 25 mg/kg bw rat oral 90-day repeated dose toxicity p.55
Regulatory source repeated dose toxicity 40 % rat oral 90-day repeated dose toxicity p.24
Regulatory source repeated dose toxicity 115 mg/kg bw rat oral 90-day repeated dose toxicity p.24
Regulatory source repeated dose toxicity 125 mg/kg bw - - prenatal repeated dose toxicity p.46
Regulatory source repeated dose toxicity 125 mg/kg bw rat - 90-day repeated dose toxicity p.52
Regulatory source repeated dose toxicity 127 mg/kg bw/day rat - 28-day repeated dose toxicity p.52
Regulatory source repeated dose toxicity 1000 mg/kg bw rat oral 90-day repeated dose toxicity p.24
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 50NP6JJ975 UNII - - - chemical -