Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Guaiacol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 750 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 42 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 42 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >42.12 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 240 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
GHS: H302 (harmful if swallowed), H315 (skin irritation), H319 (eye irritation); rabbit dermal LD50 4,600 mg/kg; Cramer Class I; RIFM assessment confirms safe under declared fragrance use levels
Regulatory Flags
Frequently Asked Questions
Is Guaiacol safe in cosmetics?
GHS: H302 (harmful if swallowed), H315 (skin irritation), H319 (eye irritation); rabbit dermal LD50 4,600 mg/kg; Cramer Class I; RIFM assessment confirms safe under declared fragrance use levels The EU classifies Guaiacol as "permitted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Guaiacol allowed in the EU?
Guaiacol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guaiacol do in cosmetics?
Guaiacol functions as: Fragrance ingredient, denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 90-05-1.
What is the Margin of Safety for Guaiacol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Guaiacol?
The NOAEL (No Observed Adverse Effect Level) for Guaiacol is 750 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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