Good Cosmetic Ingredient NOAEL Data

Butyl Benzoate

INCI: BUTYL BENZOATE

CAS Number
136-60-7
Function
Solvent, plasticizer, fragrance ingredient, masking
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Adequate based on CIR group assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Butyl Benzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH

Expert Verdict

Standard dermal irritation screening recommended for fragrance applications.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is Butyl Benzoate safe in cosmetics?

Standard dermal irritation screening recommended for fragrance applications. The EU classifies Butyl Benzoate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Butyl Benzoate allowed in the EU?

Butyl Benzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Butyl Benzoate do in cosmetics?

Butyl Benzoate functions as: Solvent, plasticizer, fragrance ingredient, masking. It is classified as a cosmetic ingredient in our database. CAS number: 136-60-7.

What is the Margin of Safety for Butyl Benzoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Butyl Benzoate?

The NOAEL (No Observed Adverse Effect Level) for Butyl Benzoate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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