Is Guaiazulene Sulfonate safe in cosmetics?
Guaiazulene Sulfonate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Guaiazulene Sulfonate
Also known as: Azulen SN, Azupromin, 3,8-Dimethyl-5-(1-methylethyl)-1-azulenesulfonic acid sodium salt, EINECS 228-309-8, Sodium guaiazulene-3-sulfonate (+7 more)
INCI: SODIUM GUAIAZULENE SULFONATE
Guaiazulene Sulfonate (CAS 6223-35-4) is a cosmetic cosmetic ingredient functioning as Surfactant, skin conditioning, soothing, anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 6223-35-4 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant, skin conditioning, soothing, anti-inflammatory
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
sodium 3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate
InChIKey
GEYJUFBPCGDENK-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions; used for soothing and surfactant properties in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guaiazulene Sulfonate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Guaiazulene Sulfonate.
Regulatory Flags
surfactant
anti-inflammatory
soothing
blue-colorant
Known Synonyms
Azulen SN
Azupromin
3,8-Dimethyl-5-(1-methylethyl)-1-azulenesulfonic acid sodium salt
EINECS 228-309-8
Sodium guaiazulene-3-sulfonate
Sodium 7-isopropyl-1,4-dimethylazulene-3-sulfonate
Guajazulen-3-sulfonsaeure, natriumsalz
Gualenate de sodium
Gualenato sodidico
Natrii gualenas
Natrium 7-isopropyl-1,4-dimethyl-3-azulensulfonat
Gualenato sodico
Chemical Function
Surfactant (surface active agent)
Regulatory Lists
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM GUALENATE
ChEMBL ID
CHEMBL1837010
Max Phase
2
Adverse Event Associations
16
Frequently Asked Questions
Is Guaiazulene Sulfonate allowed in the EU?
Guaiazulene Sulfonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guaiazulene Sulfonate do in cosmetics?
Guaiazulene Sulfonate functions as: Surfactant, skin conditioning, soothing, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 6223-35-4.
Is Guaiazulene Sulfonate used outside cosmetics?
Guaiazulene Sulfonate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guaiazulene Sulfonate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
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Ethyl Guaiazulene Sulfonate
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Sodium Guaiazulene Sulfonate
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Skin conditioning (soothing, anti-inf...
Gadi Iecur
Moderate
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Fragrance
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