NOAEL Studies Cosmetic Ingredient

Guanidine Hydrochloride NOAEL Studies

INCI: GUANIDINE HCL

CAS: 50-01-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =474 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_6715; row=12711; data_type=In Vivo; mixture=Chemical; chemical_name=Guanidine monohydrochloride; preferred_name=Guanidine monohydrochloride; dtxsid=DTXSID7058757; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7058757; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =475 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_6716; row=12710; data_type=In Vivo; mixture=Chemical; chemical_name=Guanidine monohydrochloride; preferred_name=Guanidine monohydrochloride; dtxsid=DTXSID7058757; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7058757; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =556 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_6717; row=12709; data_type=In Vivo; mixture=Chemical; chemical_name=Guanidine monohydrochloride; preferred_name=Guanidine monohydrochloride; dtxsid=DTXSID7058757; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7058757; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =773 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_6718; row=12708; data_type=In Vivo; mixture=Chemical; chemical_name=Guanidine monohydrochloride; preferred_name=Guanidine monohydrochloride; dtxsid=DTXSID7058757; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7058757; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =907 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_6719; row=12707; data_type=In Vivo; mixture=Chemical; chemical_name=Guanidine monohydrochloride; preferred_name=Guanidine monohydrochloride; dtxsid=DTXSID7058757; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7058757; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1120 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_6720; row=12706; data_type=In Vivo; mixture=Chemical; chemical_name=Guanidine monohydrochloride; preferred_name=Guanidine monohydrochloride; dtxsid=DTXSID7058757; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7058757; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOEL =25 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c8922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13899/7/6/2?documentUUID=4c2286ec-132b-48af-9df2-b9552987484e; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841839_15841840:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_220ba9f36ea6a2f1b452492706473b89
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c8922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13899/7/6/2?documentUUID=4c2286ec-132b-48af-9df2-b9552987484e; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841839_15841840:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_177bc6b94f8afcd336d36eb74f03074f
ToxValDB_ECHA_IUCLID NOEL =350 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdd4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13899/7/9/3?documentUUID=4c2286ec-132b-48af-9df2-b9552987484e; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15821101:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09913b48632ff215d006a60417c53b12
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =3.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632428:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef08afeb775622b76f1f66b4189e5caa
ToxValDB_PPRTV_(CPHEA) 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =0.02 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Multiple; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7d5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1757; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653491_15653492:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a70653d55a9418feb172b5470c289af
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3YQC9ZY4YB UNII - - - chemical {"approval_status":null,"molecular_formula":"CH5N3.ClH","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3YQC9ZY4YB"}
openFDA substances FDA UNII substance identifier 3YQC9ZY4YB UNII - - - chemical {"approval_status":null,"molecular_formula":"CH5N3.ClH","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3YQC9ZY4YB"}
openFDA substances FDA UNII substance identifier 3YQC9ZY4YB UNII - - - chemical {"approval_status":null,"molecular_formula":"CH5N3.ClH","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3YQC9ZY4YB"}
openFDA substances FDA UNII substance identifier 3YQC9ZY4YB UNII - - - chemical {"approval_status":null,"molecular_formula":"CH5N3.ClH","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3YQC9ZY4YB"}