Gynostemma Pentaphyllum Extract

INCI: GYNOSTEMMA PENTAPHYLLUM LEAF/STEM EXTRACT

CAS Number
223748-32-1 (extract); plant-derived, some suppliers list 94279-76-2
Function
Skin conditioning, antioxidant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; also used as dietary supplement

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains gypenosides (dammarane-type saponins structurally related to ginsenosides); saponins at high concentrations can be irritating; long history of traditional oral use (jiaogulan tea); limited cosmetic-specific safety studies

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Gynostemma Pentaphyllum Extract safe in cosmetics?

Contains gypenosides (dammarane-type saponins structurally related to ginsenosides); saponins at high concentrations can be irritating; long history of traditional oral use (jiaogulan tea); limited cosmetic-specific safety studies The EU classifies Gynostemma Pentaphyllum Extract as "permitted". Safety rating: GOOD.

Is Gynostemma Pentaphyllum Extract allowed in the EU?

Gynostemma Pentaphyllum Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gynostemma Pentaphyllum Extract do in cosmetics?

Gynostemma Pentaphyllum Extract functions as: Skin conditioning, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 223748-32-1 (extract); plant-derived, some suppliers list 94279-76-2.

What is the Margin of Safety for Gynostemma Pentaphyllum Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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