NOAEL Studies Cosmetic Ingredient

HC Blue No. 14 NOAEL Studies

INCI: HC BLUE NO. 14

CAS: 99788-75-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 50 mg/kg bw/day rat oral 90 day Subchronic SCCS; C. Fabreguettes. IMEXINE BJ : 13-Week Toxicity Study by Oral Route in Rats, followed by a 4-week Recovery Period. CIT Study N° 13425 TCR,
SCCNFP Opinion 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =1000 mg/kg/day - dermal 4 weeks repeated dose toxicity Ref. : 5 2, p.7
SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1000 mg/kg bw/day - - 4 weeks genotoxicity p.17
SCCS Opinion NOAEL =0.0008 mg/kg bw rat oral 13-week dermal absorption p.25
SCCS Opinion NOAEL =1000 mg/kg bw/d rat oral 13-week dermal absorption p.25
SCCS Opinion NOAEL =500 mg/kg bw/d rat oral 13-week dermal absorption p.25
SCCS Opinion NOAEL =50 % rat oral 13-week dermal absorption p.25
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 1000 mg/kg/day human - - developmental toxicity p.10
Regulatory source developmental toxicity 1000 mg/kg/day rat oral 13-week developmental toxicity p.16
Regulatory source repeated dose toxicity 1000 mg/kg/day - dermal 4 weeks repeated dose toxicity p.7
Regulatory source dermal absorption =0.0008 mg/kg bw rat oral 13-week dermal absorption p.25
Regulatory source dermal absorption =1000 mg/kg bw/d rat oral 13-week dermal absorption p.25
Regulatory source dermal absorption =500 mg/kg bw/d rat oral 13-week dermal absorption p.25
Regulatory source dermal absorption 50 % rat oral 13-week dermal absorption p.25
Regulatory source developmental toxicity 1000 mg/kg bw/day - - - developmental toxicity p.24
Regulatory source developmental toxicity 1000 mg/kg bw/day rat oral 13-week developmental toxicity p.26
Regulatory source genotoxicity 1000 mg/kg bw/day - - 4 weeks genotoxicity p.17
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier UVQ553995F UNII - - - chemical -