NOAEL Studies Cosmetic Ingredient

HC Blue No. 17 NOAEL Studies

INCI: HC BLUE NO. 17

CAS: 16517-75-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.04 mg/kg bw/d rat oral developmental repeated dose toxicity p.26
SCCS Opinion NOAEL =0.05 mg/kg bw/d rat oral subchronic repeated dose toxicity p.26
SCCS Opinion NOAEL =40 mg/kg bw/d rabbit oral Chronic genotoxicity Ref.: 1), p.17
SCCS Opinion NOAEL =100 mg/kg bw/d rat oral - NOAEL study p.23
SCCS Opinion NOAEL =200 mg/kg bw/d - - - developmental toxicity p.25
SCCS Opinion NOAEL =1000 mg/kg/day human oral - irritation p.17
SCCS Opinion NOAEL =1000 mg/kg bw/d rabbit - Chronic genotoxicity Ref.: 1), p.17
Regulatory source 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/d rat oral - - p.23
Regulatory source developmental toxicity 200 mg/kg bw/d - - - developmental toxicity p.25
Regulatory source developmental toxicity 200 mg/kg bw/d human - developmental developmental toxicity p.25
Regulatory source developmental toxicity 1000 mg/kg bw/d - - - developmental toxicity p.25
Regulatory source genotoxicity 40 mg/kg bw/d rabbit oral Chronic genotoxicity p.17
Regulatory source genotoxicity 1000 mg/kg bw/d rabbit - Chronic genotoxicity p.17
Regulatory source irritation 1000 mg/kg/day human oral - irritation p.17
Regulatory source repeated dose toxicity =0.04 mg/kg bw/d rat oral developmental repeated dose toxicity p.26
Regulatory source repeated dose toxicity =0.05 mg/kg bw/d rat oral subchronic repeated dose toxicity p.26
Regulatory source repeated dose toxicity 40 mg/kg bw/d rat oral subchronic repeated dose toxicity p.27
Regulatory source repeated dose toxicity =200 mg/kg bw/d rat oral subchronic repeated dose toxicity p.26
Regulatory source repeated dose toxicity =200 mg/kg bw/d rat oral developmental repeated dose toxicity p.26
Regulatory source repeated dose toxicity 1000 mg/kg bw/d rat oral subchronic repeated dose toxicity p.27
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8432OLU48W UNII - - - chemical -