Moderate Cosmetic Ingredient NOAEL Data

HC Blue No. 17

INCI: HC BLUE NO. 17

CAS Number
16517-75-2
Function
Hair dyeing — anthraquinone-based semi-permanent direct dye
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted under coal tar hair dye exemption (21 CFR 740.2). No specific FDA restriction.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for HC Blue No. 17. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 200 mg/kg bw/day oral - - SCCS_Perplexity

Expert Verdict

Restricted in EU to non-oxidative use with mandatory warning labeling per Annex III. Known sensitizer requiring patch-test advisories. Permitted in US under coal tar hair dye exemption.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen eu_cosing_listed

Frequently Asked Questions

Is HC Blue No. 17 safe in cosmetics?

Restricted in EU to non-oxidative use with mandatory warning labeling per Annex III. Known sensitizer requiring patch-test advisories. Permitted in US under coal tar hair dye exemption. The EU classifies HC Blue No. 17 as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is HC Blue No. 17 allowed in the EU?

HC Blue No. 17 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does HC Blue No. 17 do in cosmetics?

HC Blue No. 17 functions as: Hair dyeing — anthraquinone-based semi-permanent direct dye. It is classified as a cosmetic ingredient in our database. CAS number: 16517-75-2.

What is the Margin of Safety for HC Blue No. 17?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for HC Blue No. 17?

The NOAEL (No Observed Adverse Effect Level) for HC Blue No. 17 is 200 mg/kg bw/day based on a toxicological study via oral route in rat. Source: SCCS_Perplexity.

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