NOAEL Studies Cosmetic Ingredient

HC Blue No. 2 NOAEL Studies

INCI: HC BLUE NO. 2

CAS: 33229-34-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1992 IARC Monographs -
NTP ICE cancer 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=6318; Record_ID=cancer_1322; Data_Type=WOE; Formulation_Name=HC Blue 2; Mixture=Chemical; DTXSID=DTXSID6020193; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/75; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020193; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020193
NTP ICE cancer Top dose 10000 ppm Rat Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=6321; Record_ID=cancer_1323; Data_Type=In Vivo; Formulation_Name=HC Blue 2; Mixture=Chemical; DTXSID=DTXSID6020193; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=10000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-293; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr293/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020193; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020193
NTP ICE cancer Top dose 20000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=6315; Record_ID=cancer_1321; Data_Type=In Vivo; Formulation_Name=HC Blue 2; Mixture=Chemical; DTXSID=DTXSID6020193; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=20000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-293; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr293/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020193; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020193
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0004 mg/kg rat oral - dermal absorption p.25
SCCS Opinion NOAEL =100 mg/kg bw/day rat - Chronic genotoxicity p.14
SCCS Opinion NOAEL =100 mg/kg rat oral - dermal absorption p.25
SCCS Opinion NOAEL =100 mg/kg/day rat oral developmental developmental toxicity p.26
SCCS Opinion NOAEL =300 mg/kg/day - - - NOAEL study p.14
SCCS Opinion NOAEL =300 mg/kg bw/day human - - NOAEL study p.25
SCCS Opinion NOAEL =1000 mg/kg/day rat oral 13-week NOAEL study p.26
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =300 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7911; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10531/7/6/2?documentUUID=c251ddff-8f1f-42c5-8077-27652c2d1a18; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15831404:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2928cf22f0450fd7516a46b201064248
ECHA NOEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10531/7/9/3?documentUUID=c251ddff-8f1f-42c5-8077-27652c2d1a18; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15821823:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0baf78f1ed19acf14b6057f66b8cdf4f
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/day human - - - p.25
Regulatory source - 300 mg/kg/day - - - - p.14
Regulatory source - 300 mg/kg bw/day human - - - p.25
Regulatory source - 1000 mg/kg/day rat oral 13-week - p.26
Regulatory source dermal absorption =0.0004 mg/kg rat oral - dermal absorption p.25
Regulatory source dermal absorption =100 mg/kg rat oral - dermal absorption p.25
Regulatory source developmental toxicity 100 mg/kg/day rat oral developmental developmental toxicity p.26
Regulatory source developmental toxicity 300 mg/kg/day - - developmental developmental toxicity p.24
Regulatory source developmental toxicity 300 mg/kg/day rat oral developmental developmental toxicity p.26
Regulatory source genotoxicity 100 mg/kg bw/day rat - Chronic genotoxicity p.14
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6C0EL1931V UNII - - - chemical -