HC Blue No. 2
INCI: HC BLUE NO. 2
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for HC Blue No. 2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for HC Blue No. 2 based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Must not be used with nitrosating agents due to risk of nitrosamine formation. Rigorous nitrosamine testing mandated by SCCS. Max purity specifications and standard Annex III warnings required.
Regulatory Flags
Frequently Asked Questions
Is HC Blue No. 2 safe in cosmetics?
Must not be used with nitrosating agents due to risk of nitrosamine formation. Rigorous nitrosamine testing mandated by SCCS. Max purity specifications and standard Annex III warnings required. The EU classifies HC Blue No. 2 as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is HC Blue No. 2 allowed in the EU?
HC Blue No. 2 EU regulatory status: restricted. Maximum allowed concentration: 2.8%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Blue No. 2 do in cosmetics?
HC Blue No. 2 functions as: Hair dyeing - nitroaminophenol-type semi-permanent direct dye. It is classified as a cosmetic ingredient in our database. CAS number: 33229-34-4.
What is the Margin of Safety for HC Blue No. 2?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for HC Blue No. 2?
The NOAEL (No Observed Adverse Effect Level) for HC Blue No. 2 is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
Check HC Blue No. 2 compliance across multiple jurisdictions:
Related Ingredients
Is HC Blue No. 2 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for HC Blue No. 2 in your formulation.