NOAEL Studies Cosmetic Ingredient

HC Orange No. 6 NOAEL Studies

INCI: HC ORANGE NO. 6

CAS: 1449653-83-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =300 mg/kg bw/day rat - Chronic genotoxicity p.18
SCCS Opinion NOAEL =100 mg/kg/day - - developmental developmental toxicity p.25
SCCS Opinion NOAEL =300 mg/kg/day - - developmental developmental toxicity p.25
SCCS Opinion NOAEL =10 mg/kg bw rat oral prenatal developmental toxicity p.26
SCCS Opinion NOAEL =100 mg/kg bw/d rat oral prenatal developmental toxicity p.26
SCCS Opinion NOAEL =50 mg/kg bw/d rat oral prenatal developmental toxicity p.26
SCCS Opinion NOAEL =19 % rat oral 90 days repeated dose toxicity p.27
SCCS Opinion NOAEL =100 mg/kg - dermal developmental developmental toxicity p.27
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 100 mg/kg/day - - developmental developmental toxicity p.25
Regulatory source developmental toxicity 100 mg/kg - - developmental developmental toxicity p.25
Regulatory source developmental toxicity 300 mg/kg/day - - developmental developmental toxicity p.25
Regulatory source developmental toxicity 10 mg/kg bw rat oral prenatal developmental toxicity p.26
Regulatory source developmental toxicity =100 mg/kg bw/d rat oral prenatal developmental toxicity p.26
Regulatory source developmental toxicity =50 mg/kg bw/d rat oral prenatal developmental toxicity p.26
Regulatory source developmental toxicity 300 mg/kg/day rat - 90 days developmental toxicity p.27
Regulatory source developmental toxicity 100 mg/kg - dermal developmental developmental toxicity p.27
Regulatory source genotoxicity 300 mg/kg bw/day rat - Chronic genotoxicity p.18
Regulatory source repeated dose toxicity 19 % rat oral 90 days repeated dose toxicity p.27
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier PKS7O14JK4 UNII - - - chemical -