NOAEL Studies Cosmetic Ingredient

HC RED NO. 1 NOAEL Studies

CAS: 2784-89-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 2 mg/kg bw/day rat oral 91 day Subchronic SCCP; A 91-Day Oral Gavage Toxicity Study With GTS03974 In Rats With A 28-Day RecoveryPhase, P&G study # 2746-53896, July 2005
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0294 mg/kg rat oral subchronic repeated dose toxicity p.33
SCCS Opinion NOAEL =5 mg/kg bw/d rabbit oral 13 weeks NOAEL study p.16
SCCS Opinion NOAEL =5 mg/kg rat oral subchronic repeated dose toxicity p.33
SCCS Opinion NOAEL =20 mg/kg bw/d rabbit oral - NOAEL study p.16
SCCS Opinion NOAEL =25 mg/kg/day - oral developmental developmental toxicity p.31
SCCS Opinion NOAEL =50 mg/kg bw/d rat oral 91-day repeated dose toxicity p.14
SCCS Opinion NOAEL =125 mg/kg bw/d - - developmental developmental toxicity p.31
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 5 mg/kg bw/d rabbit oral 13 weeks - p.16
Regulatory source - 20 mg/kg bw/d rabbit oral - - p.16
Regulatory source developmental toxicity 25 mg/kg/day - oral developmental developmental toxicity p.31
Regulatory source developmental toxicity 125 mg/kg bw/d - - developmental developmental toxicity p.31
Regulatory source repeated dose toxicity =0.0294 mg/kg rat oral subchronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity =5 mg/kg rat oral subchronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity 5 mg/kg bw/d rat oral subchronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity 25 mg/kg/day rat oral subchronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity 50 mg/kg bw/d rat oral 91-day repeated dose toxicity p.14
Regulatory source repeated dose toxicity 125 mg/kg bw/d mouse dermal subchronic repeated dose toxicity p.33
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1FZM1701IS UNII - - - chemical -