NOAEL Studies Cosmetic Ingredient

HC Red No. 10 NOAEL Studies

INCI: HC RED NO. 10

CAS: Verify against current CosIng - chemical names listed include 1-Amino-2-nitro-4-(2',3'-dihydroxypropyl)amino-5-chlorobenzene and 1,4-Bis-(2',3'-dihydroxypropyl)amino-2-nitro-5-chlorobenzene

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =40 mg/kg bw rat oral 90-day irritation p.5
SCCS Opinion NOAEL =0.0022 mg/kg bw rat dermal 90-day dermal absorption p.5
SCCS Opinion NOAEL =20 mg/kg bw/d rat - 6 weeks NOAEL study p.23
SCCS Opinion NOAEL =100 mg/kg bw/d human - - NOAEL study p.29
SCCS Opinion NOAEL =0.7 mg/kg bw/d - oral subchronic repeated dose toxicity p.30
SCCS Opinion NOAEL =0.006 mg/kg bw/d rat oral 90 d dermal absorption p.31
SCCS Opinion NOAEL =10.4 mg/kg bw/d rat oral 90 d dermal absorption p.31
SCCS Opinion NOAEL =0.004 mg/kg bw/d rat oral 90 d dermal absorption p.31
SCCS Opinion NOAEL =0.0008 mg/kg bw/d rat oral 90 d dermal absorption p.31
SCCS Opinion NOAEL =7.1 mg/kg bw/d rat oral 90 d dermal absorption p.31
SCCS Opinion NOAEL =0.0006 mg/kg bw/d rat oral 90 d dermal absorption p.32
SCCS Opinion NOAEL =35.4 % - oral subchronic repeated dose toxicity p.33
Regulatory source 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 mg/kg bw/d rat - 6 weeks - p.23
Regulatory source - 20 mg/kg bw/d - - 6 weeks - p.23
Regulatory source - 100 mg/kg bw/d human - - - p.29
Regulatory source dermal absorption 0.0022 mg/kg bw rat dermal 90-day dermal absorption p.5
Regulatory source dermal absorption =0.006 mg/kg bw/d rat oral 90 d dermal absorption p.31
Regulatory source dermal absorption =10.4 mg/kg bw/d rat oral 90 d dermal absorption p.31
Regulatory source dermal absorption =0.004 mg/kg bw/d rat oral 90 d dermal absorption p.31
Regulatory source dermal absorption =0.0008 mg/kg bw/d rat oral 90 d dermal absorption p.31
Regulatory source dermal absorption =7.1 mg/kg bw/d rat oral 90 d dermal absorption p.31
Regulatory source dermal absorption =0.0006 mg/kg bw/d rat oral 90 d dermal absorption p.32
Regulatory source irritation 40 mg/kg bw rat oral 90-day irritation p.5
Regulatory source repeated dose toxicity 20 mg/kg bw/d human oral subchronic repeated dose toxicity p.30
Regulatory source repeated dose toxicity 0.7 mg/kg bw/d - oral subchronic repeated dose toxicity p.30
Regulatory source repeated dose toxicity 20 mg/kg bw/d rat oral sub-chronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity 100 mg/kg bw/d rat oral sub-chronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity 35.4 % - oral subchronic repeated dose toxicity p.33