Moderate Cosmetic Ingredient Sensitization Data

HC Red No. 10

INCI: HC RED NO. 10

CAS Number
Verify against current CosIng - chemical names listed include 1-Amino-2-nitro-4-(2',3'-dihydroxypropyl)amino-5-chlorobenzene and 1,4-Bis-(2',3'-dihydroxypropyl)amino-2-nitro-5-chlorobenzene
Function
Hair dyeing (direct/semi-permanent dye)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Falls under the coal tar hair dye exemption; permitted with caution labeling and patch test advisory

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for HC Red No. 10 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: SCCS; IVDK

Expert Verdict

SCCS safety evaluation completed; typical nitro dye concerns apply (sensitization, genotoxicity screening); the chloro-nitro-diamine structure warrants careful purity specification to minimize impurities. Nitro dye with hydroxypropyl functional groups enhancing solubility and hair affinity; the chlorobenzene backbone provides stable red chromophore; semi-permanent application without oxidative developer

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is HC Red No. 10 safe in cosmetics?

SCCS safety evaluation completed; typical nitro dye concerns apply (sensitization, genotoxicity screening); the chloro-nitro-diamine structure warrants careful purity specification to minimize impurities. Nitro dye with hydroxypropyl functional groups enhancing solubility and hair affinity; the chlorobenzene backbone provides stable red chromophore; semi-permanent application without oxidative developer The EU classifies HC Red No. 10 as "restricted". Safety rating: MODERATE.

Is HC Red No. 10 allowed in the EU?

HC Red No. 10 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does HC Red No. 10 do in cosmetics?

HC Red No. 10 functions as: Hair dyeing (direct/semi-permanent dye). It is classified as a cosmetic ingredient in our database. CAS number: Verify against current CosIng - chemical names listed include 1-Amino-2-nitro-4-(2',3'-dihydroxypropyl)amino-5-chlorobenzene and 1,4-Bis-(2',3'-dihydroxypropyl)amino-2-nitro-5-chlorobenzene.

What is the Margin of Safety for HC Red No. 10?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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