NOAEL Studies Cosmetic Ingredient

HC Red No. 18 NOAEL Studies

INCI: HC RED NO. 18

CAS: 1444596-49-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =100 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.19
SCCS Opinion NOAEL =3 mg/kg bw/day rat oral 91 days genotoxicity p.22
SCCS Opinion NOAEL =50 mg/kg bw/day rat - prenatal developmental toxicity p.28
SCCS Opinion NOAEL =77 % rat oral - irritation p.32
SCCS Opinion NOAEL =3 mg/kg/day rat - 90-day repeated dose toxicity p.35
SCCS Opinion NOAEL =0.013 mg/kg bw rat oral 90-day dermal absorption p.35
SCCS Opinion NOAEL =3 mg/kg bw/d rat oral 90-day dermal absorption p.35
SCCS Opinion NOAEL =2.31 mg/kg bw/d rat oral 90-day dermal absorption p.35
SCCS Opinion NOAEL =0.022 mg/kg bw rat oral 90-day NOAEL study (ref. 12), p.35
Regulatory source 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption =0.013 mg/kg bw rat oral 90-day dermal absorption p.35
Regulatory source dermal absorption =3 mg/kg bw/d rat oral 90-day dermal absorption p.35
Regulatory source dermal absorption =2.31 mg/kg bw/d rat oral 90-day dermal absorption p.35
Regulatory source developmental toxicity 50 mg/kg bw/day rat - prenatal developmental toxicity p.28
Regulatory source developmental toxicity 50 mg/kg bw/day rat oral developmental developmental toxicity p.29
Regulatory source developmental toxicity 3 mg/kg bw/day rat oral 14-day developmental toxicity p.36
Regulatory source developmental toxicity 50 mg/kg bw/day rat oral 90 days developmental toxicity p.36
Regulatory source genotoxicity 3 mg/kg bw/day rat oral 91 days genotoxicity p.22
Regulatory source irritation 77 % rat oral - irritation p.32
Regulatory source repeated dose toxicity 100 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.19
Regulatory source repeated dose toxicity 3 mg/kg/day rat - 90-day repeated dose toxicity p.35
Regulatory source repeated dose toxicity 3 mg/kg/day rat oral 90-day repeated dose toxicity p.37
Regulatory source repeated dose toxicity 77 % rat oral 90-day repeated dose toxicity p.37