NOAEL Studies Cosmetic Ingredient

HC Yellow No. 10 NOAEL Studies

INCI: HC YELLOW NO. 10

CAS: 109023-83-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 25 mg/kg bw/day rat oral 93 day Subchronic SCCP; C.Mc Alinden. Imexine FAH: 13-week Oral (Gavage) Toxicity Study in the Rat. ToxicolLaboratories, Report N°LRL/79/94, 1995
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =500 mg/kg bw rat oral 28-day dermal absorption p.5
SCCS Opinion NOAEL =125 mg/kg/day - oral 93 days NOAEL study p.13
SCCS Opinion NOAEL =100 mg/kg/day - - - NOAEL study p.13
SCCS Opinion NOAEL =0.0016 mg/kg rat oral 90-day dermal absorption p.19
SCCS Opinion NOAEL =100 mg/kg rat oral 90-day dermal absorption p.19
SCCS Opinion NOAEL =2000 mg/kg rat oral 90-day developmental toxicity p.19
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 125 mg/kg/day - oral 93 days - p.13
Regulatory source - 100 mg/kg/day - - - - p.13
Regulatory source dermal absorption 500 mg/kg bw rat oral 28-day dermal absorption p.5
Regulatory source dermal absorption =0.0016 mg/kg rat oral 90-day dermal absorption p.19
Regulatory source dermal absorption =100 mg/kg rat oral 90-day dermal absorption p.19
Regulatory source developmental toxicity 100 mg/kg/day rat - - developmental toxicity p.18
Regulatory source developmental toxicity 2000 mg/kg rat oral 90-day developmental toxicity p.19
Regulatory source developmental toxicity 100 mg/kg/day rat oral 90-day developmental toxicity p.19
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier VQY3VF9106 UNII - - - chemical -