NOAEL Studies Cosmetic Ingredient

HC Yellow No. 2 NOAEL Studies

INCI: HC YELLOW NO. 2

CAS: 4926-55-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 5 mg/kg bw/day rat oral 91 day Subchronic SCCS; A 91-Day Oral Gavage Toxicity Study With GTS03975 in Rats with a 28-Day RecoveryPhase, P&G study # 2747-53907, July 12, 2005
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.05 mg/kg bw/d rat oral 90-day dermal absorption p.32
SCCS Opinion NOAEL =0.08 mg/kg bw/d rat oral 90-day dermal absorption p.32
SCCS Opinion NOAEL =50 mg/kg bw/d rat oral Chronic NOAEL study p.19
SCCS Opinion NOAEL =99.88 % rat oral 90-day repeated dose toxicity p.32
SCCS Opinion NOAEL =500 mg/kg bw/d rat oral developmental developmental toxicity p.30
SCCS Opinion NOAEL =625 mg/kg bw rat oral subchronic repeated dose toxicity p.32
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL ~50 mg/kg bw/day Rat oral chronic; 91 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c885c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22290/7/6/2?documentUUID=bcef1609-8ff5-4d14-9e28-d41fbd397ab5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=clinical signs|gross pathology|haematology|histopathology: non-neoplastic|mortality|ophthalmological examination; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology|hematology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15846343:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba88ca44aea8183b00ae9996d2f70bf3
ECHA NOAEL =500 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdd22; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22290/7/9/3?documentUUID=bcef1609-8ff5-4d14-9e28-d41fbd397ab5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821118_15821587:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efeef4b12553154675219fdd327f69b3
ECHA NOAEL =600 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb41e4b0a7c65d225626; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22290/7/6/2?documentUUID=bcef1609-8ff5-4d14-9e28-d41fbd397ab5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=clinical signs|gross pathology|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology|mortality/survival; STUDY_GROUP=ECHA IUCLID:15838937:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7bb079c306344839b727921091bd276c
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 50 mg/kg bw/d rat oral Chronic - p.19
Regulatory source dermal absorption =0.05 mg/kg bw/d rat oral 90-day dermal absorption p.32
Regulatory source dermal absorption =0.08 mg/kg bw/d rat oral 90-day dermal absorption p.32
Regulatory source dermal absorption =50 mg/kg bw/d rat oral 90-day dermal absorption p.32
Regulatory source developmental toxicity 500 mg/kg bw/d rat oral developmental developmental toxicity p.30
Regulatory source repeated dose toxicity 50 mg/kg bw/d rat oral subchronic repeated dose toxicity p.32
Regulatory source repeated dose toxicity 99.88 % rat oral 90-day repeated dose toxicity p.32
Regulatory source repeated dose toxicity 500 mg/kg bw/d rat oral subchronic repeated dose toxicity p.32
Regulatory source repeated dose toxicity 625 mg/kg bw rat oral subchronic repeated dose toxicity p.32
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9FVT2KMV9O UNII - - - chemical -