NOAEL Studies Cosmetic Ingredient

HC Yellow No. 9 NOAEL Studies

INCI: HC YELLOW NO. 9

CAS: 86419-69-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =100 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity Ref.: 20 (subm, p.18
SCCS Opinion NOAEL =250 mg/kg bw/day rat - - NOAEL study Ref.: 5 (subm, p.19
SCCS Opinion NOAEL =80 mg/kg bw/day rat - Chronic genotoxicity Ref.: 5 (subm, p.19
SCCS Opinion NOAEL =70 mg/kg bw/day mouse oral - developmental toxicity Ref.: 10 (subm, p.24
SCCS Opinion NOAEL =0.09 mg/kg bw rat dermal - dermal absorption p.25
SCCS Opinion NOAEL =70 mg/kg bw/d rat dermal - dermal absorption p.25
SCCS Opinion NOAEL =250 mg/kg bw/d rat oral subchronic repeated dose toxicity p.26
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 250 mg/kg bw/day rat - - - p.19
Regulatory source dermal absorption =0.09 mg/kg bw rat dermal - dermal absorption p.25
Regulatory source dermal absorption =70 mg/kg bw/d rat dermal - dermal absorption p.25
Regulatory source developmental toxicity 70 mg/kg bw/day mouse oral - developmental toxicity p.24
Regulatory source genotoxicity 80 mg/kg bw/day rat - Chronic genotoxicity p.19
Regulatory source genotoxicity 250 mg/kg bw/day - - Chronic genotoxicity p.19
Regulatory source repeated dose toxicity 100 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 250 mg/kg bw/d rat oral subchronic repeated dose toxicity p.26
Regulatory source reproductive toxicity 70 mg/kg bw/d rat oral - reproductive toxicity p.26
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 91P0Z9H61V UNII - - - chemical -