Also known as: 2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester, Ethylene glycol monomethacrylate, 4-02-00-01530, BRN 1071583, EINECS 212-782-2 (+12 more)
INCI: 2-HYDROXYETHYL METHACRYLATE
HEMA (2-Hydroxyethyl Methacrylate) (CAS 868-77-9) is a cosmetic cosmetic ingredient functioning as Monomer in artificial nail modelling systems (UV/LED gel nails). NOAEL 0.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 35%; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
US NotesPermitted — no FDA-specific concentration limit or professional-use restriction for cosmetic nail products; however, MoCRA general safety provisions apply
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HEMA (2-Hydroxyethyl Methacrylate).
Calculate MoS for your specific formulation with the
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Toxicological Studies
2 study endpoints found for HEMA (2-Hydroxyethyl Methacrylate). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=100 mg/kg bw/day
oral
Rat
subchronic
ToxValDB_ECHA_IUCLID
NOAEL
=300 mg/kg bw/day
oral
Rat
subchronic
ToxValDB_ECHA_IUCLID
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarnCancerHealth haz
Hazard Statements
May be harmful if swallowed Causes skin and eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. See Notes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for HEMA (2-Hydroxyethyl Methacrylate) across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for HEMA (2-Hydroxyethyl Methacrylate) based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
2.3%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis
Source: ESSCA 2019/20
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
H315Causes skin irritation
H319Causes serious eye irritation
H317May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification:Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Nail products.
BRIN Brazil/India Cosmetics
India: Restricted
Additional Ingredient Properties
1 property record from structured ingredient metadata.
Indirect additives food contact (10/2018)Arts and crafts/Office supplies; Europeair; Cons electronics mech appliances and machinery; detected; emissions; EuropeEurope; Personal care - nails
Australian Status
AICIS status:listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Is HEMA (2-Hydroxyethyl Methacrylate) safe in cosmetics?
HEMA (2-Hydroxyethyl Methacrylate) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Is HEMA (2-Hydroxyethyl Methacrylate) allowed in the EU?
HEMA (2-Hydroxyethyl Methacrylate) EU regulatory status: restricted. Maximum allowed concentration: 35%. This is based on EU Regulation 1223/2009 and its amendments.
What does HEMA (2-Hydroxyethyl Methacrylate) do in cosmetics?
HEMA (2-Hydroxyethyl Methacrylate) functions as: Monomer in artificial nail modelling systems (UV/LED gel nails). It is classified as a cosmetic ingredient in our database. CAS number: 868-77-9.
What is the NOAEL for HEMA (2-Hydroxyethyl Methacrylate)?
The NOAEL (No Observed Adverse Effect Level) for HEMA (2-Hydroxyethyl Methacrylate) is =100 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is HEMA (2-Hydroxyethyl Methacrylate) classified as hazardous under GHS?
HEMA (2-Hydroxyethyl Methacrylate) carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed Causes skin and eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is HEMA (2-Hydroxyethyl Methacrylate) used outside cosmetics?
HEMA (2-Hydroxyethyl Methacrylate) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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