Heparin

INCI: HEPARIN

CAS Number
9005-49-6
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted as cosmetic ingredient but heparin is primarily regulated as a drug (anticoagulant) by FDA; cosmetic use must not make drug claims

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Drug-cosmetic borderline: claims of anti-inflammatory or circulation-boosting action could reclassify product as a drug; bovine/porcine sourcing raises BSE/TSE contamination and religious/ethical concerns; heparin-induced thrombocytopenia risk negligible via dermal route but assessor must document rationale

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Concern Level: Moderate

Frequently Asked Questions

Is Heparin safe in cosmetics?

Drug-cosmetic borderline: claims of anti-inflammatory or circulation-boosting action could reclassify product as a drug; bovine/porcine sourcing raises BSE/TSE contamination and religious/ethical concerns; heparin-induced thrombocytopenia risk negligible via dermal route but assessor must document rationale The EU classifies Heparin as "permitted". Safety rating: MODERATE.

Is Heparin allowed in the EU?

Heparin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Heparin do in cosmetics?

Heparin functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9005-49-6.

What is the Margin of Safety for Heparin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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