NOAEL Studies Cosmetic Ingredient

Heptanol NOAEL Studies

INCI: HEPTANOL

CAS: 111-70-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 50 mg/kg bw/day rabbit oral 182 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1051; row=13358; data_type=In Vivo; mixture=Chemical; chemical_name=1-Heptanol; preferred_name=1-Heptanol; dtxsid=DTXSID8021937; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3250 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1052; row=13357; data_type=In Vivo; mixture=Chemical; chemical_name=1-Heptanol; preferred_name=1-Heptanol; dtxsid=DTXSID8021937; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =5500 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1053; row=13359; data_type=In Vivo; mixture=Chemical; chemical_name=1-Heptanol; preferred_name=1-Heptanol; dtxsid=DTXSID8021937; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6200 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1054; row=13360; data_type=In Vivo; mixture=Chemical; chemical_name=1-Heptanol; preferred_name=1-Heptanol; dtxsid=DTXSID8021937; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1124; RecordID=ARPathway2016_575; DatasetName=ARPathway2016; DTXSID=DTXSID8021937; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3653; Record_ID=skin_sensitization_invivo_908; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021937; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90181-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937
NTP_ICE_skin_sensitization Induction dose per skin area 648 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3651; Record_ID=skin_sensitization_invivo_908; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021937; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90181-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3655; Record_ID=skin_sensitization_invivo_908; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021937; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90181-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021937
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =1100 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4cbb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/26500?documentUUID=ec142a0e-c92a-4d31-b7bb-59cda2ba29ee; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830363_15830364_15832281_15832282_15843563_15843564:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bb3fa030a071e93ee1c87b31cee4ba06
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4cbb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/26500?documentUUID=ec142a0e-c92a-4d31-b7bb-59cda2ba29ee; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830363_15830364_15832281_15832282_15843563_15843564:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f819ecf435dc5aa231937639e73fab3
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =35.26 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632443:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fc274aacc66dd4a8e3ee91e9c118a24
openFDA substances 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8JQ5607IO5 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JQ5607IO5"}
openFDA substances FDA UNII substance identifier 8JQ5607IO5 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JQ5607IO5"}
openFDA substances FDA UNII substance identifier 8JQ5607IO5 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JQ5607IO5"}