Is Heptanol safe in cosmetics?
Heptanol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Heptanol
Also known as: 4-01-00-01731, Alcohol C-7, BRN 1731686, EINECS 203-897-9, Enanthyl alcohol (+11 more)
INCI: HEPTANOL
Heptanol (CAS 111-70-6) is a cosmetic cosmetic ingredient functioning as Fragrance, Viscosity Controlling. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 111-70-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Viscosity Controlling
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
heptan-1-ol
InChIKey
BBMCTIGTTCKYKF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted, not restricted in 21 CFR for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Heptanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Heptanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | =100 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure at high levels could cause effects on the central nervous system.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Heptanol across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 648 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1082
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (4)
JECFA Number
94
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALCOHOL C-7 | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ENANTHIC ALCOHOL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEPTYL ALCOHOL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Heptanol.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Heptanol by CAS number or substance name.
Studies
2
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
4-01-00-01731
Alcohol C-7
BRN 1731686
EINECS 203-897-9
Enanthyl alcohol
Fatty alcohol(C7)
FEMA No. 2548
FEMA Number 2548
Heptyl alcohol, primary
Hexyl carbinol
Hydroxy heptane
Hydroxyheptane
Pri-n-heptyl alcohol
l'Alcool N-heptylique primaire
N-Heptanol-1
UNII-8JQ5607IO5
Chemical Function
Flavouring and nutrient
Fragrance
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
1-HEPTANOL
ChEMBL ID
CHEMBL273459
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
HEPTYL ALCOHOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Heptanol allowed in the EU?
Heptanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Heptanol do in cosmetics?
Heptanol functions as: Fragrance, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 111-70-6.
What is the NOAEL for Heptanol?
The NOAEL (No Observed Adverse Effect Level) for Heptanol is 50 mg/kg bw/day based on a Subchronic study via oral route in rabbit. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Heptanol used outside cosmetics?
Heptanol also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Heptanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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