Is Hesperidin Methyl Chalcone safe in cosmetics?
Hesperidin Methyl Chalcone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hesperidin Methyl Chalcone
Also known as: Hesperidin methylchalcone
INCI: HESPERIDIN METHYL CHALCONE
Hesperidin Methyl Chalcone (CAS 24292-52-2) is a cosmetic cosmetic ingredient functioning as Antioxidant; vascular permeability modifier used in eye contour products to. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 24292-52-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; vascular permeability modifier used in eye contour products to reduce dark circles
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(E)-3-(3-hydroxy-4-methoxyphenyl)-1-[2-hydroxy-6-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxyphenyl]prop-2-en-1-one
InChIKey
FDHNLHLOJLLXDH-JIYHLSBYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR reviewed (2023 Final Report) — found safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hesperidin Methyl Chalcone.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Hesperidin Methyl Chalcone.
Known Synonyms
Hesperidin methylchalcone
Chemical Function
Antioxidant
Regulatory Lists
active_ingredient; Australia
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL5435071
Frequently Asked Questions
Is Hesperidin Methyl Chalcone allowed in the EU?
Hesperidin Methyl Chalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hesperidin Methyl Chalcone do in cosmetics?
Hesperidin Methyl Chalcone functions as: Antioxidant; vascular permeability modifier used in eye contour products to reduce dark circles. It is classified as a cosmetic ingredient in our database. CAS number: 24292-52-2.
Is Hesperidin Methyl Chalcone used outside cosmetics?
Hesperidin Methyl Chalcone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hesperidin Methyl Chalcone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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