NOAEL Studies Cosmetic Ingredient

Hesperidin NOAEL Studies

INCI: HESPERIDIN

CAS: 520-26-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 25 mg/kg bw/day rat oral 224 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 30 mg/kg bw/day rat oral 175 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 50 mg/kg bw/day rat oral 224 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 150 mg/kg bw/day mouse oral 224 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 200 mg/kg bw/day rat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 200 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3600 mg/kg bw/day mouse oral 158 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 400 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 8000 mg/kg bw/day rat other: - developmental toxicity dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=7f7ec9b6-dc59-4bd1-bc36-61a13e384551_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=7f7ec9b6-dc59-4bd1-bc36-61a13e384551/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-05-30; basis=other:; key_result=false; entry_uuid=4afdfc92-3ecf-49a2-ab26-0d01bb9a70f6
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 750 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=8d5c0785-d0ef-4190-b029-6a8d5390aaf8_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=8d5c0785-d0ef-4190-b029-6a8d5390aaf8/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; ReportDate=1939-07-09; key_result=false; entry_uuid=528ae64e-b0f5-4994-9160-fbcc3192ac18
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=3300 mg/kg bw/day rat oral: feed - developmental toxicity dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=17e12ea4-3e72-4143-9847-79fbbb9122f9_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=17e12ea4-3e72-4143-9847-79fbbb9122f9/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-06-10; basis=other:; key_result=false; entry_uuid=6828da04-a28b-4932-bb90-4137159e4b66
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 8000 mg/kg bw/day rat other: - developmental toxicity dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=7f7ec9b6-dc59-4bd1-bc36-61a13e384551_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=7f7ec9b6-dc59-4bd1-bc36-61a13e384551/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-05-30; basis=other:; key_result=false; entry_uuid=4afdfc92-3ecf-49a2-ab26-0d01bb9a70f6
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 750 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=8d5c0785-d0ef-4190-b029-6a8d5390aaf8_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=8d5c0785-d0ef-4190-b029-6a8d5390aaf8/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; ReportDate=1939-07-09; key_result=false; entry_uuid=528ae64e-b0f5-4994-9160-fbcc3192ac18
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=3300 mg/kg bw/day rat oral: feed - developmental toxicity dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=17e12ea4-3e72-4143-9847-79fbbb9122f9_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=17e12ea4-3e72-4143-9847-79fbbb9122f9/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-06-10; basis=other:; key_result=false; entry_uuid=6828da04-a28b-4932-bb90-4137159e4b66
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 8000 mg/kg bw/day rat other: - developmental toxicity dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=7f7ec9b6-dc59-4bd1-bc36-61a13e384551_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=7f7ec9b6-dc59-4bd1-bc36-61a13e384551/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-05-30; basis=other:; key_result=false; entry_uuid=4afdfc92-3ecf-49a2-ab26-0d01bb9a70f6
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 750 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=8d5c0785-d0ef-4190-b029-6a8d5390aaf8_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=8d5c0785-d0ef-4190-b029-6a8d5390aaf8/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; ReportDate=1939-07-09; key_result=false; entry_uuid=528ae64e-b0f5-4994-9160-fbcc3192ac18
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=3300 mg/kg bw/day rat oral: feed - developmental toxicity dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=17e12ea4-3e72-4143-9847-79fbbb9122f9_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=17e12ea4-3e72-4143-9847-79fbbb9122f9/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-06-10; basis=other:; key_result=false; entry_uuid=6828da04-a28b-4932-bb90-4137159e4b66
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 200 mg/kg bw/day rat oral: gavage - fertility, other dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=eb83c890-8749-4bd6-af55-91442d42a025_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=eb83c890-8749-4bd6-af55-91442d42a025/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; ReportDate=2017-07-05; basis=other:; key_result=false; entry_uuid=ac89c38c-95fe-4360-a155-1e614f461137
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 200 mg/kg bw/day rat oral: gavage - fertility, other dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=eb83c890-8749-4bd6-af55-91442d42a025_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=eb83c890-8749-4bd6-af55-91442d42a025/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; ReportDate=2017-07-05; basis=other:; key_result=false; entry_uuid=ac89c38c-95fe-4360-a155-1e614f461137
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 200 mg/kg bw/day rat oral: gavage - fertility, other dossier=ebe79210-6c19-45eb-81ed-cc2128d765d8.i6z; document=eb83c890-8749-4bd6-af55-91442d42a025_ebe79210-6c19-45eb-81ed-cc2128d765d8.i6d; document_key=eb83c890-8749-4bd6-af55-91442d42a025/ebe79210-6c19-45eb-81ed-cc2128d765d8; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; ReportDate=2017-07-05; basis=other:; key_result=false; entry_uuid=ac89c38c-95fe-4360-a155-1e614f461137
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =750 mg/kg bw/day Rat oral chronic; 200 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae5ae4b0a7c65d1c8cf0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25219/7/6/2?documentUUID=ebe79210-6c19-45eb-81ed-cc2128d765d8; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15839044:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c60f20c306c42038315d0f6ee60c029a
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =52.89 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632445:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e805264e4061d39968dc9441666ea2ca
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier E750O06Y6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H34O15","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E750O06Y6O"}
openFDA substances FDA UNII substance identifier E750O06Y6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H34O15","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E750O06Y6O"}
openFDA substances FDA UNII substance identifier E750O06Y6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H34O15","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E750O06Y6O"}
openFDA substances FDA UNII substance identifier E750O06Y6O UNII - - - chemical {"approval_status":null,"molecular_formula":"C28H34O15","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E750O06Y6O"}