Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hesperidin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3600 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
High molecular weight limits both absorption and bioavailability topically with no significant safety concerns at typical cosmetic concentrations.
Regulatory Flags
Frequently Asked Questions
Is Hesperidin safe in cosmetics?
High molecular weight limits both absorption and bioavailability topically with no significant safety concerns at typical cosmetic concentrations. The EU classifies Hesperidin as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Hesperidin allowed in the EU?
Hesperidin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hesperidin do in cosmetics?
Hesperidin functions as: Antioxidant, skin conditioning, anti-inflammatory, vascular protectant. It is classified as a cosmetic ingredient in our database. CAS number: 520-26-3.
What is the Margin of Safety for Hesperidin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hesperidin?
The NOAEL (No Observed Adverse Effect Level) for Hesperidin is 3600 mg/kg bw/day based on a Reproductive study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Hesperidin compliance across multiple jurisdictions:
Related Ingredients
Is Hesperidin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hesperidin in your formulation.