EXCELLENT Cosmetic Ingredient NOAEL Data

Hesperidin

Also known as: 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-, 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-, 5-18-05-00218, 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-, BRN 0075140 (+15 more)

INCI: HESPERIDIN

Hesperidin (CAS 520-26-3) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning, anti-inflammatory, vascular protectant. NOAEL 750 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.

View industrial chemical safety profile for CAS 520-26-3 →

CAS Number

520-26-3

View industrial chemical safety profile →

Function

Antioxidant, skin conditioning, anti-inflammatory, vascular protectant

Editorial assessment

EXCELLENT

Preliminary editorial note — not a computed safety verdict.

Chemistry & Identifiers

Formula

C28H34O15

610.6 g/mol

EC Number

208-288-1

PubChem CID

10621

IUPAC Name

(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one

InChIKey

QUQPHWDTPGMPEX-QJBIFVCTSA-N

ChEBI: CHEBI:28775 UNII: E750O06Y6O Wikidata: Q385937

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes Permitted — no specific restrictions under 21 CFR; GRAS precedent for food use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Hesperidin.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

7 study endpoints found for Hesperidin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	100 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS DB
NOAEL	150 mg/kg bw/day	oral	mouse	Chronic	COSMOS DB
NOAEL	200 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS DB
NOAEL	1000 mg/kg bw/day	oral	rat	Chronic	COSMOS DB
NOAEL	3600 mg/kg bw/day	oral	mouse	Reproductive	COSMOS DB
NOAEL	5000 mg/kg bw/day	oral	rat	Chronic	COSMOS DB
NOAEL	=750 mg/kg bw/day	oral	Rat	chronic	ECHA

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Hesperidin across SCCS product categories, with measured dermal absorption where available.

EPA ToxValDB — Toxicity Values

2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint	Value	Species	Route	Duration	Source
LD50	>2000 mg/kg	Rat	oral	-	ECHA
NOAEL	=750 mg/kg-day	Rat	oral	chronic	ECHA

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Flavouring and nutrient Softener and conditioner

Regulatory List Membership (1)

FDA Substances Added to Food (EAFUS)

Editorial summary

Preliminary editorial summary for Hesperidin — not a computed safety verdict. See the sourced toxicological data above.

Regulatory Flags

fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Hesperidin by CAS number or substance name.

Studies

Lowest NOAEL

100 mg/kg bw/day

Highest NOAEL

5000 mg/kg bw/day

COSMOS DB ECHA

Known Synonyms

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)- 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)- 5-18-05-00218 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)- BRN 0075140 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, (S)- EINECS 208-288-1 Glucopyranoside, hesperetin-7 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D- Hesperetin, 7-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside) Hesperetin-7-O-rhamnoglucoside Hesperidin, (S)-(-)- Hesperidin, (2S)- Hesperitin-7-rhamnoglucoside 7-(6-O-Desoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanon 3',5'-Dihydroxy-4'-methoxy-7-rutinosyloxyflavan-4-on Hesperetin-rutinosid 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyl)oxy)-4-chromanon Hesper bitabs UNII-E750O06Y6O (S)-(-)-hesperidin

Chemical Function

Softener and conditioner Flavouring and nutrient

Regulatory Lists

active_ingredient; animal_products; Europe; pharmaceutical; residue food_additive; Substances Added to Food (formerly EAFUS) (2/2019) Canada; pharmaceutical Canada; pharmaceutical

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical and food safety data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

HESPERIDIN

ChEMBL ID

CHEMBL449317

Max Phase

Adverse Event Associations

View full pharmaceutical profile →

SOURCE EFSA / FDA GRAS food_additives

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name

Hesperidin

Food Category

preservative

View full food safety profile →

Frequently Asked Questions

Is Hesperidin safe in cosmetics?

Hesperidin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 7 toxicological study endpoint(s) are available in our database.

Is Hesperidin allowed in the EU?

Hesperidin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hesperidin do in cosmetics?

Hesperidin functions as: Antioxidant, skin conditioning, anti-inflammatory, vascular protectant. It is classified as a cosmetic ingredient in our database. CAS number: 520-26-3.

What is the NOAEL for Hesperidin?

The NOAEL (No Observed Adverse Effect Level) for Hesperidin is 100 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS DB.

Is Hesperidin used outside cosmetics?

Hesperidin also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

Check Hesperidin compliance across multiple jurisdictions:

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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