NOAEL Studies
Cosmetic Ingredient
Hexadecene NOAEL Studies
INCI: HEXADECENE
CAS: 629-73-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=1ccd6c1a-8f39-48de-b0d5-c9ec3fa5701c_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=1ccd6c1a-8f39-48de-b0d5-c9ec3fa5701c/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2014; ReportDate=2014-09-25; basis=other:; key_result=false; entry_uuid=5a0c311f-250c-4386-adc3-2007618774c8 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=35fd0c15-deba-4f53-91ce-64eaa7d2dfa7_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=35fd0c15-deba-4f53-91ce-64eaa7d2dfa7/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-11-26; basis=other:; key_result=true; entry_uuid=30f5fdf8-f25e-4635-a20d-835b845f3935 |
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=356ec51c-4ccb-4377-80ac-7ef949ac5048_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=356ec51c-4ccb-4377-80ac-7ef949ac5048/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-09-13; basis=other:; key_result=true; entry_uuid=172d9b1f-8477-43fc-a728-3cb4ba25c318 |
| ECHA | NOAEL | 101 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: short-term oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=6976d5c8-db81-4d7d-bc28-ac198727e693_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=6976d5c8-db81-4d7d-bc28-ac198727e693/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-03-11; basis=other:; key_result=false; entry_uuid=8ce131d9-6366-4f78-a65b-7ad7016a829c |
| ECHA | NOAEL | 1010 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: short-term oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=6976d5c8-db81-4d7d-bc28-ac198727e693_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=6976d5c8-db81-4d7d-bc28-ac198727e693/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-03-11; basis=other:; key_result=false; entry_uuid=213f55e7-cadb-4a5c-98a0-1f0d64156651 |
| ECHA | NOAEL | 350 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=813a9118-80f5-46a4-b91a-3b5c9fb57f0d_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=813a9118-80f5-46a4-b91a-3b5c9fb57f0d/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-10-19; basis=other:; key_result=true; entry_uuid=d6938f35-f72d-4673-95f4-47875affdb46 |
| ECHA | NOEL | 100 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=35fd0c15-deba-4f53-91ce-64eaa7d2dfa7_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=35fd0c15-deba-4f53-91ce-64eaa7d2dfa7/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-11-26; basis=other:; key_result=true; entry_uuid=b1115c5e-aa51-4075-b0aa-542d3a8f2460 |
| ECHA | NOEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=6dc108e0-e132-41f3-8b16-4661fe223cc7_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=6dc108e0-e132-41f3-8b16-4661fe223cc7/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-12-17; basis=other:; key_result=true; entry_uuid=80fb1015-6ef9-4f3c-8156-f56f0571add8 |
| ECHA | NOEL | 300 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=51899e8e-bc18-48f8-a715-720c2f463f2d_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=51899e8e-bc18-48f8-a715-720c2f463f2d/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2014; ReportDate=2014-09-25; basis=other:; key_result=false; entry_uuid=dc042bd7-f722-4c32-abb0-53dc717d1e1c |
| ECHA | NOEL | 20 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=b443d846-af53-4b51-adc8-49624a78c2a1.i6z; document=356ec51c-4ccb-4377-80ac-7ef949ac5048_b443d846-af53-4b51-adc8-49624a78c2a1.i6d; document_key=356ec51c-4ccb-4377-80ac-7ef949ac5048/b443d846-af53-4b51-adc8-49624a78c2a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-09-13; basis=other:; key_result=true; entry_uuid=408e530c-704a-415b-b80d-4647d2ffa759 |
| ECHA | NOAEC | =3000 | ppm | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14268/7/6/3?documentUUID=b443d846-af53-4b51-adc8-49624a78c2a1; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827555_15827741_15828760_15829361:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c02545fea78c031c3466ddbbded49179 |
| ECHA | NOAEC | =27537.8 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24127/7/6/3?documentUUID=7933be68-1fe2-4a51-860d-9bd58510dfd1; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827441_15828385_15828486:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c86fd9dac2e6f45da601d415e7ab1f8 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22efb7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=4fe025e2-ef92-4551-85e2-1e9ca4048c2c; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821977_15822156_15822182_15822245_15822303_15822320_15823527:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3219d188583454b4d1a7dd3bb0067020 |
| ECHA | NOEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22efb7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=4fe025e2-ef92-4551-85e2-1e9ca4048c2c; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820624_15820812_15820843_15820906_15820967_15820990_15823349:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6fb957424efa6f178b6ef73a75a76cd9 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 97T015M2UX | UNII | - | - | - | chemical | - |