NOAEL Studies Cosmetic Ingredient

Hexamidine NOAEL Studies

INCI: HEXAMIDINE

CAS: 3811-75-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =50 mg/kg/day rat oral subchronic repeated dose toxicity {"citation":"0; 71; 2","dose":"The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day.","effect":"was not stored in any tissue type. Hexamidine Diisethionate given to rats intra- venously was rapidly metabolized to Hexamidine. Excretion was primarily via the feces, with a small amount excreted in the urine. Acute oral LD50 values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hex- amidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aque- ous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethion- ate applied to 10% of the body surface...","page":1,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_001"}
CIR_vision_codex NOAEL =0.4 % rabbit dermal 90 days repeated dose toxicity {"citation":"4; 0; 05","dose":"A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level).","effect":"Hexamidine Diisethionate in rabbits. The trunks of the animals were clipped free of hair. A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level). Applications were repeated daily for 90 days. No mortalities occurred. No reac- tions or signs of dermal irritation were observed. No remark- able observations were made at gross necropsy or microscopic examination of tissues. Hematological parameters were normal for all dose groups. The no-observed-effect level (NOEL) was 0.4% Hexamidine Diisethionate in this study. Chronic Toxicity No published data were available on the chronic toxicity of Hexamidine or Hexamidine Diisethionate. Ocular Toxicity Lamarche (1972) instilled 0.1 ml of 0.05% or 0.10% Hex- amidine Diisethionate in aqueous solution to the right eye of albino rabbits (n = 9 rabbits/dose level). For each dose level, three animals’ eyes were rinsed with lukewarm water exactly 2 s after application of the test material, three animals’ eyes were rinsed after 4 s, and three animals’ eyes were not r...","page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_002"}
CIR_vision_codex NOAEL =50 - Sprague-Dawley rats oral gavage 28 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"powell_1987_oral_28d_rat"}
CIR_vision_codex NOAEL =0.4 - rabbits dermal 90 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"lamarche_1972_dermal_90d_rabbit"}
CIR_vision_codex NOAEL =50 mg/kg/day rat oral subchronic repeated dose toxicity {"citation":"0; 71; 2","dose":"The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day.","effect":"was not stored in any tissue type. Hexamidine Diisethionate given to rats intra- venously was rapidly metabolized to Hexamidine. Excretion was primarily via the feces, with a small amount excreted in the urine. Acute oral LD50 values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hex- amidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aque- ous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethion- ate applied to 10% of the body surface...","page":1,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_001"}
CIR_vision_codex NOAEL =0.4 % rabbit dermal 90 days repeated dose toxicity {"citation":"4; 0; 05","dose":"A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level).","effect":"Hexamidine Diisethionate in rabbits. The trunks of the animals were clipped free of hair. A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level). Applications were repeated daily for 90 days. No mortalities occurred. No reac- tions or signs of dermal irritation were observed. No remark- able observations were made at gross necropsy or microscopic examination of tissues. Hematological parameters were normal for all dose groups. The no-observed-effect level (NOEL) was 0.4% Hexamidine Diisethionate in this study. Chronic Toxicity No published data were available on the chronic toxicity of Hexamidine or Hexamidine Diisethionate. Ocular Toxicity Lamarche (1972) instilled 0.1 ml of 0.05% or 0.10% Hex- amidine Diisethionate in aqueous solution to the right eye of albino rabbits (n = 9 rabbits/dose level). For each dose level, three animals’ eyes were rinsed with lukewarm water exactly 2 s after application of the test material, three animals’ eyes were rinsed after 4 s, and three animals’ eyes were not r...","page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_002"}
CIR_vision_codex NOAEL =50 - Sprague-Dawley rats oral gavage 28 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"powell_1987_oral_28d_rat"}
CIR_vision_codex NOAEL =0.4 - rabbits dermal 90 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"lamarche_1972_dermal_90d_rabbit"}
CIR_vision_codex NOAEL =50 mg/kg/day rat oral subchronic repeated dose toxicity {"citation":"0; 71; 2","dose":"The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day.","effect":"was not stored in any tissue type. Hexamidine Diisethionate given to rats intra- venously was rapidly metabolized to Hexamidine. Excretion was primarily via the feces, with a small amount excreted in the urine. Acute oral LD50 values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hex- amidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aque- ous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethion- ate applied to 10% of the body surface...","page":1,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_001"}
CIR_vision_codex NOAEL =0.4 % rabbit dermal 90 days repeated dose toxicity {"citation":"4; 0; 05","dose":"A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level).","effect":"Hexamidine Diisethionate in rabbits. The trunks of the animals were clipped free of hair. A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level). Applications were repeated daily for 90 days. No mortalities occurred. No reac- tions or signs of dermal irritation were observed. No remark- able observations were made at gross necropsy or microscopic examination of tissues. Hematological parameters were normal for all dose groups. The no-observed-effect level (NOEL) was 0.4% Hexamidine Diisethionate in this study. Chronic Toxicity No published data were available on the chronic toxicity of Hexamidine or Hexamidine Diisethionate. Ocular Toxicity Lamarche (1972) instilled 0.1 ml of 0.05% or 0.10% Hex- amidine Diisethionate in aqueous solution to the right eye of albino rabbits (n = 9 rabbits/dose level). For each dose level, three animals’ eyes were rinsed with lukewarm water exactly 2 s after application of the test material, three animals’ eyes were rinsed after 4 s, and three animals’ eyes were not r...","page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_002"}
CIR_vision_codex NOAEL =50 - Sprague-Dawley rats oral gavage 28 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"powell_1987_oral_28d_rat"}
CIR_vision_codex NOAEL =0.4 - rabbits dermal 90 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"lamarche_1972_dermal_90d_rabbit"}
CIR_vision_codex NOAEL =50 mg/kg/day rat oral subchronic repeated dose toxicity {"citation":"0; 71; 2","dose":"The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day.","effect":"was not stored in any tissue type. Hexamidine Diisethionate given to rats intra- venously was rapidly metabolized to Hexamidine. Excretion was primarily via the feces, with a small amount excreted in the urine. Acute oral LD50 values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hex- amidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aque- ous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethion- ate applied to 10% of the body surface...","page":1,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_001"}
CIR_vision_codex NOAEL =0.4 % rabbit dermal 90 days repeated dose toxicity {"citation":"4; 0; 05","dose":"A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level).","effect":"Hexamidine Diisethionate in rabbits. The trunks of the animals were clipped free of hair. A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level). Applications were repeated daily for 90 days. No mortalities occurred. No reac- tions or signs of dermal irritation were observed. No remark- able observations were made at gross necropsy or microscopic examination of tissues. Hematological parameters were normal for all dose groups. The no-observed-effect level (NOEL) was 0.4% Hexamidine Diisethionate in this study. Chronic Toxicity No published data were available on the chronic toxicity of Hexamidine or Hexamidine Diisethionate. Ocular Toxicity Lamarche (1972) instilled 0.1 ml of 0.05% or 0.10% Hex- amidine Diisethionate in aqueous solution to the right eye of albino rabbits (n = 9 rabbits/dose level). For each dose level, three animals’ eyes were rinsed with lukewarm water exactly 2 s after application of the test material, three animals’ eyes were rinsed after 4 s, and three animals’ eyes were not r...","page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"PRS365_noael_002"}
CIR_vision_codex NOAEL =50 - Sprague-Dawley rats oral gavage 28 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"powell_1987_oral_28d_rat"}
CIR_vision_codex NOAEL =0.4 - rabbits dermal 90 days NOAEL study {"page":6,"pdf":"PRS365.pdf","row_type":"noael_study","study_id":"lamarche_1972_dermal_90d_rabbit"}
UnifiedCodex:CIR:beta.noael_studies 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:CIR:beta.noael_studies - 50 - Sprague-Dawley rats oral gavage 28 days - SOURCE_SUBDIR=PRS365; REPORT_TITLE=Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate; OPINION_NUMBER=PRS365; COMMITTEE=safe for use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%; REPORT_DATE=2007; VALUE_TEXT=50 mg/kg/day; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"3811-75-4","citation":"","dose":"","duration":"28 days","effect":"","endpoint":"","ingredient":"Hexamidine","loael_value":"","noael_unit":"","noael_value":"50 mg/kg/day","page":6,"route":"oral gavage","species":"Sprague-Dawley rats","study_id":"powell_1987_oral_28d_rat"}
UnifiedCodex:CIR:beta.noael_studies - 50 - male rats oral gavage 12 weeks, 5 days per week - SOURCE_SUBDIR=PRS365; REPORT_TITLE=Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate; OPINION_NUMBER=PRS365; COMMITTEE=safe for use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%; REPORT_DATE=2007; VALUE_TEXT=not explicitly stated; NOEL referenced in summary as 50 mg/kg/day for 4-week study; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"3811-75-4","citation":"","dose":"","duration":"12 weeks, 5 days per week","effect":"","endpoint":"","ingredient":"Hexamidine","loael_value":"","noael_unit":"","noael_value":"not explicitly stated; NOEL referenced in summary as 50 mg/kg/day for 4-week study","page":6,"route":"oral gavage","species":"male rats","study_id":"colipa_1982_oral_12wk_rat"}
UnifiedCodex:CIR:beta.noael_studies - 0.4 - rabbits dermal 90 days - SOURCE_SUBDIR=PRS365; REPORT_TITLE=Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate; OPINION_NUMBER=PRS365; COMMITTEE=safe for use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%; REPORT_DATE=2007; VALUE_TEXT=0.4% (NOEL); CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"3811-75-4","citation":"","dose":"","duration":"90 days","effect":"","endpoint":"","ingredient":"Hexamidine","loael_value":"","noael_unit":"","noael_value":"0.4% (NOEL)","page":6,"route":"dermal","species":"rabbits","study_id":"lamarche_1972_dermal_90d_rabbit"}
UnifiedCodex:CIR:beta.noael_studies repeated dose toxicity 50 mg/kg/day rat oral subchronic repeated dose toxicity SOURCE_SUBDIR=PRS365; REPORT_TITLE=Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate; OPINION_NUMBER=PRS365; COMMITTEE=safe for use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%; REPORT_DATE=2007; VALUE_TEXT=50; DOSE=The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day.; EFFECT=was not stored in any tissue type. Hexamidine Diisethionate given to rats intra- venously was rapidly metabolized to Hexamidine. Excretion was primarily via the feces, with a small amount excreted in the urine. Acute oral LD50 values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hex- amidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aque- ous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethion- ate applied to 10% of the body surface...; CITATION=0; 71; 2; CITATION_NUMBERS=[71,2]; REFERENCE=0; 71; 2; DETAILS_JSON={"cas_number":"3811-75-4","citation":"0; 71; 2","dose":"The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day.","duration":"subchronic","effect":"was not stored in any tissue type. Hexamidine Diisethionate given to rats intra- venously was rapidly metabolized to Hexamidine. Excretion was primarily via the feces, with a small amount excreted in the urine. Acute oral LD50 values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hex- amidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aque- ous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethion- ate applied to 10% of the body surface...","endpoint":"repeated dose toxicity","ingredient":"Hexamidine","loael_value":"","noael_unit":"mg/kg/day","noael_value":"50","page":1,"route":"oral","species":"rat","study_id":"PRS365_noael_001"}
UnifiedCodex:CIR:beta.noael_studies repeated dose toxicity 0.4 % rabbit dermal 90 days repeated dose toxicity SOURCE_SUBDIR=PRS365; REPORT_TITLE=Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate; OPINION_NUMBER=PRS365; COMMITTEE=safe for use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%; REPORT_DATE=2007; VALUE_TEXT=0.4; DOSE=A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level).; EFFECT=Hexamidine Diisethionate in rabbits. The trunks of the animals were clipped free of hair. A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level). Applications were repeated daily for 90 days. No mortalities occurred. No reac- tions or signs of dermal irritation were observed. No remark- able observations were made at gross necropsy or microscopic examination of tissues. Hematological parameters were normal for all dose groups. The no-observed-effect level (NOEL) was 0.4% Hexamidine Diisethionate in this study. Chronic Toxicity No published data were available on the chronic toxicity of Hexamidine or Hexamidine Diisethionate. Ocular Toxicity Lamarche (1972) instilled 0.1 ml of 0.05% or 0.10% Hex- amidine Diisethionate in aqueous solution to the right eye of albino rabbits (n = 9 rabbits/dose level). For each dose level, three animals’ eyes were rinsed with lukewarm water exactly 2 s after application of the test material, three animals’ eyes were rinsed after 4 s, and three animals’ eyes were not r...; CITATION=4; 0; 05; CITATION_NUMBERS=[4,5]; REFERENCE=4; 0; 05; DETAILS_JSON={"cas_number":"3811-75-4","citation":"4; 0; 05","dose":"A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level).","duration":"90 days","effect":"Hexamidine Diisethionate in rabbits. The trunks of the animals were clipped free of hair. A glass rod was used to apply 4 ml/kg of 0.05%, 0.1%, 0.2%, or 0.4% Hexamidine Diisethionate over a 240-cm2 area (n = 3 rabbits/dose level). Applications were repeated daily for 90 days. No mortalities occurred. No reac- tions or signs of dermal irritation were observed. No remark- able observations were made at gross necropsy or microscopic examination of tissues. Hematological parameters were normal for all dose groups. The no-observed-effect level (NOEL) was 0.4% Hexamidine Diisethionate in this study. Chronic Toxicity No published data were available on the chronic toxicity of Hexamidine or Hexamidine Diisethionate. Ocular Toxicity Lamarche (1972) instilled 0.1 ml of 0.05% or 0.10% Hex- amidine Diisethionate in aqueous solution to the right eye of albino rabbits (n = 9 rabbits/dose level). For each dose level, three animals’ eyes were rinsed with lukewarm water exactly 2 s after application of the test material, three animals’ eyes were rinsed after 4 s, and three animals’ eyes were not r...","endpoint":"repeated dose toxicity","ingredient":"Hexamidine","loael_value":"","noael_unit":"%","noael_value":"0.4","page":6,"route":"dermal","species":"rabbit","study_id":"PRS365_noael_002"}
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3483C2H13H UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H26N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3483C2H13H"}
openFDA substances FDA UNII substance identifier 3483C2H13H UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H26N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3483C2H13H"}
openFDA substances FDA UNII substance identifier 3483C2H13H UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H26N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3483C2H13H"}
openFDA substances FDA UNII substance identifier 3483C2H13H UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H26N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3483C2H13H"}