NOAEL Studies
Cosmetic Ingredient
Hexanal NOAEL Studies
INCI: HEXANAL
CAS: 66-25-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 1.05 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 95.6999969482 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | PAFA; BULL ENV CONTAM TOXICOL 41:515-522 |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=1e6aa5d2-2066-4d86-8733-e078d9418d4f.i6z; document=de66dcc7-6499-4b96-8475-e5d8d515b04e_1e6aa5d2-2066-4d86-8733-e078d9418d4f.i6d; document_key=de66dcc7-6499-4b96-8475-e5d8d515b04e/1e6aa5d2-2066-4d86-8733-e078d9418d4f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2019; ReportDate=2019-02-04; basis=clinical signs; key_result=true; entry_uuid=cee0c90f-6353-4f1a-972f-3e9768a5b146 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=1e6aa5d2-2066-4d86-8733-e078d9418d4f.i6z; document=de66dcc7-6499-4b96-8475-e5d8d515b04e_1e6aa5d2-2066-4d86-8733-e078d9418d4f.i6d; document_key=de66dcc7-6499-4b96-8475-e5d8d515b04e/1e6aa5d2-2066-4d86-8733-e078d9418d4f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2019; ReportDate=2019-02-04; basis=clinical signs; key_result=true; entry_uuid=cee0c90f-6353-4f1a-972f-3e9768a5b146 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=1e6aa5d2-2066-4d86-8733-e078d9418d4f.i6z; document=de66dcc7-6499-4b96-8475-e5d8d515b04e_1e6aa5d2-2066-4d86-8733-e078d9418d4f.i6d; document_key=de66dcc7-6499-4b96-8475-e5d8d515b04e/1e6aa5d2-2066-4d86-8733-e078d9418d4f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2019; ReportDate=2019-02-04; basis=clinical signs; key_result=true; entry_uuid=cee0c90f-6353-4f1a-972f-3e9768a5b146 |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4890 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9059; row=3959; data_type=In Vivo; mixture=Chemical; chemical_name=Hexanal; preferred_name=Hexanal; dtxsid=DTXSID2021604; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021604; source_file=acute_oral.xlsx |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9310; Record_ID=skin_sensitization_invivo_2061; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021604; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90072-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021604 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 648 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9308; Record_ID=skin_sensitization_invivo_2061; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021604; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90072-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021604 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9314; Record_ID=skin_sensitization_invivo_2061; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021604; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90072-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021604 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =16.46 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632511:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ac4338013762b64178f555f416a5e65 |
openFDA substances 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |
| openFDA substances | FDA UNII substance identifier | 9DC2K31JJQ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9DC2K31JJQ"} |