Is Hexanal safe in cosmetics?
Hexanal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexanal
Also known as: Hexaldehyde, C6 aldehyde, 4-01-00-03296, Aldehyde C-6, BRN 0506198 (+9 more)
INCI: HEXANAL
Hexanal (CAS 66-25-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (Aldehyde C-6). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 66-25-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient (Aldehyde C-6)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
hexanal
InChIKey
JARKCYVAAOWBJS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no specific 21 CFR prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexanal.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hexanal across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 648 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
Vapor: irritating to eyes, nose & throat...Liquid: irritating to skin & eyes
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (4)
JECFA Number
92
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALDEHYDE C-6 | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CAPROIC ALDEHYDE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXANAL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexanal.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hexanal by CAS number or substance name.
Studies
3
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Hexaldehyde
C6 aldehyde
4-01-00-03296
Aldehyde C-6
BRN 0506198
n-Caproic aldehyde
n-Caproylaldehyde
EINECS 200-624-5
FEMA No. 2557
FEMA Number 2557
n-Hexaldehyde
Hexoic aldehyde
Kapronaldehyd
UNII-9DC2K31JJQ
Chemical Function
Deodorizer
No specific technical function
Flavouring and nutrient
Fragrance
Regulatory Lists
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Cons electronics mech appliances and machinery; detected; emissions; Europe
artificial_saliva; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
air; Cleaning products and household care - air freshener; detected; emissions
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HEXANAL
ChEMBL ID
CHEMBL280331
Frequently Asked Questions
Is Hexanal allowed in the EU?
Hexanal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexanal do in cosmetics?
Hexanal functions as: Fragrance ingredient (Aldehyde C-6). It is classified as a cosmetic ingredient in our database. CAS number: 66-25-1.
Is Hexanal used outside cosmetics?
Hexanal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexanal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Glucosamine HCl
Excellent
Chemical family
pH Adjuster, Skin Conditioning, Anti-...
Pyridoxal
Good
Chemical family
Skin conditioning agent, antioxidant
Uracil
Good
Chemical family
Skin conditioning agent, hair conditi...
Is Hexanal in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexanal in your formulation.