NOAEL Studies Cosmetic Ingredient

HEXANEDIOL NOAEL Studies

CAS: 629-11-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_8617; row=2803; data_type=In Vivo; mixture=Chemical; chemical_name=1,6-Hexanediol; preferred_name=1,6-Hexanediol; dtxsid=DTXSID1027265; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027265; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3730 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8619; row=2802; data_type=In Vivo; mixture=Chemical; chemical_name=1,6-Hexanediol; preferred_name=1,6-Hexanediol; dtxsid=DTXSID1027265; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027265; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =400 mg/kg bw/day Rat oral subchronic; 42 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb67e4b0a7c65d22605f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26453/7/6/2?documentUUID=0594086a-c7c2-412e-8e9c-32c58c3bdeff; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833990_15847248:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_34e8f1ca85934389350a4e29e437412c
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9cd0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15109/7/6/2?documentUUID=cc9a9fbf-9339-4ae2-bcd3-0bffb9744d6d; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15848430:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dcc68bd8ec543c69cb6fdedfc19a3e16
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral subchronic; 42 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9cc8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15109/7/6/2?documentUUID=cc9a9fbf-9339-4ae2-bcd3-0bffb9744d6d; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833990_15847248:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8678998fe4425d039179e5d01b7feb4f
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =35 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632520:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0762888c581face3f4b15e41de4865db
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ZIA319275I UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZIA319275I"}
openFDA substances FDA UNII substance identifier ZIA319275I UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZIA319275I"}
openFDA substances FDA UNII substance identifier ZIA319275I UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZIA319275I"}
openFDA substances FDA UNII substance identifier ZIA319275I UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZIA319275I"}