NOAEL Studies Cosmetic Ingredient

Hexene (1-Hexene) NOAEL Studies

INCI: HEXENE

CAS: 592-41-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 110.0822 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2421; Record_ID=acute_inhalation_1248; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4025402; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=110.0822; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4025402; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4025402
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =41306.7 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15516063:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff86d7e65166cd859ee88c7ab9435088
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEC =10326.7 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e2e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24127/7/6/3?documentUUID=d355de57-5c3a-4c24-a245-77f6788b6b8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826929_15826956_15827004_15827031_15827068_15827096_15827128:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1f681e8a8f73432b44a3740b3f30219
ToxValDB_ECHA_IUCLID NOAEL =350 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb32e4b0a7c65d22524f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12539?documentUUID=af3320ce-e366-4095-9903-e7d1c3a90eb8; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15838675:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99c36e25b96a1298bb614e9334150d9b
ToxValDB_ECHA_IUCLID NOAEL =101 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca35e4b0a7c65d220b50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12539?documentUUID=af3320ce-e366-4095-9903-e7d1c3a90eb8; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15845437:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edf54bc6ac33bb06094271a3f67f4420
ToxValDB_ECHA_IUCLID NOAEL =1010 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca35e4b0a7c65d220b50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12539?documentUUID=af3320ce-e366-4095-9903-e7d1c3a90eb8; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15845438:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_27e9a9197b94ec4997b636b5fc4493e4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier B38ZZ8C206 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B38ZZ8C206"}
openFDA substances FDA UNII substance identifier B38ZZ8C206 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B38ZZ8C206"}
openFDA substances FDA UNII substance identifier B38ZZ8C206 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B38ZZ8C206"}
openFDA substances FDA UNII substance identifier B38ZZ8C206 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B38ZZ8C206"}